Comparison Prophylactic Effects of Gargling Different Doses of Ketamine on Attenuating Postoperative Sore Throat: A Single-Blind Randomized Controlled Trial.

Autor: Kheirabadi D; Anesthesiology and Critical Care Research Center, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran., Ardekani MS; General Physician, School of medicine, Isfahan University of Medical Sciences, Isfahan, Iran., Honarmand A; Anesthesiology and Critical Care Research Center, Department of Anesthesiology and Critical Care, Isfahan University of Medical Sciences, Isfahan, Iran., Safavi MR; Anesthesiology and Critical Care Research Center, Department of Anesthesiology and Critical Care, Isfahan University of Medical Sciences, Isfahan, Iran., Salmasi E; School of Medicine, Najaf Abad University of Medical Sciences, Isfahan, Iran.
Jazyk: angličtina
Zdroj: International journal of preventive medicine [Int J Prev Med] 2021 Jun 25; Vol. 12, pp. 62. Date of Electronic Publication: 2021 Jun 25 (Print Publication: 2021).
DOI: 10.4103/ijpvm.IJPVM_147_19
Abstrakt: Context: Postoperative sore throat (POST) is a common annoying problem following endotracheal (ET) intubation.
Aims: Comparing the impact of low and high doses of ketamine gargle on lowering POST incidence and severity.
Settings and Design: 96 patients selected for septoplasty surgery under general anesthesia were investigated through a single-blind randomized controlled trial.
Methods: This study was performed on three equal groups. Group K and G gargled 50 and 100 mg ketamine, respectively, solved in normal saline and group C gargled pure normal saline for 30 s at 5 min before tracheal intubation. POST severity measured immediately after the entrance to the postanesthetic care unit (PACU) and then 2 h, 4 h, 8 h, and 24 h after operation.
Statistical Analysis Used: Collected data were analyzed by the Chi-square test, Mann-Whitney test, Kruskal-Wallis test, one-way analysis of variance (ANOVA) and Friedman test using SPSS version 20.
Results: POST incidence and severity in group C were significantly higher than both K and G groups at all times. Although significant differences between low and high doses of ketamine were acknowledged at 8 h post-operation, 100 mg ketamine could attenuate POST severity further than 50 mg at all times.
Conclusions: It seems that 100 mg outperformed 50 mg ketamine without rising complications and dissatisfaction for subjects. So, it gives us a powerful reason to suggest gargling 100 mg ketamine for lessening POST incidence and severity.
Competing Interests: There are no conflicts of interest.
(Copyright: © 2021 International Journal of Preventive Medicine.)
Databáze: MEDLINE
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