| Autor: |
Rosa Neto JC; Immunometabolism Research Group, Department of Cell Biology and Development, Institute of Biomedical Science, University of Sao Paulo, Sao Paulo 05508-000, Brazil.; LIM-26, Hospital das Clínicas of the University of São Paulo, Sao Paulo 01246-903, Brazil., Calder PC; Faculty of Medicine, School of Human Development and Health, University of Southampton, Southampton SO16 6YD, UK.; National Institute for Health Research Southampton Biomedical Research Centre, University of Southampton and University Hospital Southampton National Health Service (NHS) Foundation Trust, Southampton SO16 6YD, UK.; Institute for Life Sciences, University of Southampton, Southampton SO17 1BJ, UK., Curi R; Interdisciplinary Post-Graduate Program in Health Sciences, Cruzeiro do Sul University, Sao Paulo 01506-000, Brazil., Newsholme P; Curtin Medical School and Curtin Health Innovation Research Institute, Curtin University, Perth, WA 6102, Australia., Sethi JK; Faculty of Medicine, School of Human Development and Health, University of Southampton, Southampton SO16 6YD, UK.; National Institute for Health Research Southampton Biomedical Research Centre, University of Southampton and University Hospital Southampton National Health Service (NHS) Foundation Trust, Southampton SO16 6YD, UK.; Institute for Life Sciences, University of Southampton, Southampton SO17 1BJ, UK., Silveira LS; Immunometabolism Research Group, Department of Cell Biology and Development, Institute of Biomedical Science, University of Sao Paulo, Sao Paulo 05508-000, Brazil. |
| Abstrakt: |
Macrophages and lymphocytes demonstrate metabolic plasticity, which is dependent partly on their state of activation and partly on the availability of various energy yielding and biosynthetic substrates (fatty acids, glucose, and amino acids). These substrates are essential to fuel-based metabolic reprogramming that supports optimal immune function, including the inflammatory response. In this review, we will focus on metabolism in macrophages and lymphocytes and discuss the role of fatty acids in governing the phenotype, activation, and functional status of these important cells. We summarize the current understanding of the pathways of fatty acid metabolism and related mechanisms of action and also explore possible new perspectives in this exciting area of research. |
