miRNA-146a and miRNA-126 as Potential Biomarkers in Patients with Coronary Artery Disease and Generalized Periodontitis.

Autor: Mahendra J; Department of Periodontology, Meenakshi Ammal Dental College and Hospital, Chennai 600095, India., Mahendra L; Department of Periodontics, Maktoum Bin Hamdan Dental College, Dubai 213620, United Arab Emirates., Fageeh HN; Department of Preventive Dental Sciences, College of Dentistry, Jazan University, Jazan 45142, Saudi Arabia., Fageeh HI; Department of Preventive Dental Sciences, College of Dentistry, Jazan University, Jazan 45142, Saudi Arabia., Ibraheem W; Department of Preventive Dental Sciences, College of Dentistry, Jazan University, Jazan 45142, Saudi Arabia., Abdulkarim HH; Advanced Periodontal and Dental Implant Care, Missouri School of Dentistry and Oral Health, A. T. Still University, St. Louis, MO 63104, USA., Kanakamedala A; Department of Periodontology, Meenakshi Ammal Dental College and Hospital, Chennai 600095, India., Prakash P; Department of Periodontology, Meenakshi Ammal Dental College and Hospital, Chennai 600095, India., Srinivasan S; Department of Periodontology, Meenakshi Ammal Dental College and Hospital, Chennai 600095, India., Balaji TM; Department of Periodontology, Tagore Dental College and Hospital, Chennai 600127, India., Varadarajan S; Department of Oral Pathology and Microbiology, Sri Venkateswara Dental College and Hospital, Chennai 600130, India., Jagannathan R; Department of Periodontology, Tagore Dental College and Hospital, Chennai 600127, India., Patil S; Department of Maxillofacial Surgery and Diagnostic Sciences, Division of Oral Pathology, College of Dentistry, Jazan University, Jazan 45142, Saudi Arabia.
Jazyk: angličtina
Zdroj: Materials (Basel, Switzerland) [Materials (Basel)] 2021 Aug 20; Vol. 14 (16). Date of Electronic Publication: 2021 Aug 20.
DOI: 10.3390/ma14164692
Abstrakt: The present study aims to compare the levels of micro-RNA-146a and micro-RNA-126 in oral subgingival plaque and coronary plaque from artery walls in patients with coronary artery disease who suffer from generalized periodontitis. A total of 75 participants were selected and grouped into three categories of 25 patients each: GP+CAD, GP, and HP groups. GP+CAD consisted of patients diagnosed with generalized periodontitis (GP) and coronary artery disease (CAD). The GP+CAD group was further divided into two groups-GP+CADa: where subgingival plaque samples were collected; GP+CADb group: where coronary plaque samples were collected while the patient underwent a coronary artery bypass grafting surgery. The GP group consisted of 25 patients diagnosed with only generalized periodontitis. The HP group consisted of 25 systemically and periodontally healthy controls. miRNA-146a and miRNA126 levels were assessed in subgingival plaque (SP) samples from all groups. Results revealed that miRNA-146a was expressed at higher levels and miRNA-126 was downregulated in the GP+CAD group. microRNAs in subgingival plaque samples showed a significant correlation with the coronary plaque samples in the GP+CAD group. miRNA-146a and miRNA-126 were present in coronary artery disease patients with periodontitis. These micro-RNAs may serve as risk biomarkers for coronary artery disease and generalized periodontitis.
Databáze: MEDLINE
Externí odkaz: