| Autor: |
Lu Y; JL Operating Theatres, Royal Prince Alfred Hospital, Camperdown 2050, Australia., Ussher N; Rural Clinical School, University of New South Wales, Sydney 2052, Australia., Zhou Y; Xiamen Cardiovascular Hospital, Xiamen University, Xiamen 361005, China.; The School of Economics, Xiamen University, Xiamen 361005, China., Jelinek H; Health Sciences, Charles Sturt University, Albury 2640, Australia., Hambly B; Department of Pathology, University of Sydney, Sydney 2006, Australia.; Center for Healthy Futures, Torrens University, Pyrmont 2009, Australia., Li A; Center for Healthy Futures, Torrens University, Pyrmont 2009, Australia.; Department of Pharmacy & Biomedical Sciences, La Trobe University, Flora Hill 3552, Australia., McLachlan CS; Center for Healthy Futures, Torrens University, Pyrmont 2009, Australia. |
| Abstrakt: |
Matrix metalloproteinases (MMPs) are enzymes that are integral in extracellular matrix (ECM) remodeling. In age or disease, ECM may become dysregulated and contribute to fibrosis, which impairs cardiac electrical conduction. Two alleles regulate matrix metalloproteinase-3 (MMP-3) activity: one with five adenosine bases (5A; associated with higher MMP-3 activity and decreased fibrosis) and another with six adenosine bases (6A; associated with lower MMP-3 activity and increased fibrosis). Here, we determined whether ECG-derived QTc and related parameters are associated with the MMP-3 5A/6A genotype in a cross-section of the Australian rural population. A retrospective cross-sectional population was obtained from the Charles Sturt University Diabetes Screening Research Initiative. Genotype and resting 12-lead ECG parameters of 295 participants were analyzed. Amongst these participants, 85 individuals carried the 5A/5A genotype, 141 individuals carried the 5A/6A genotype, and 65 individuals carried the 6A/6A genotype. Compared to 5A/5A genotype carriers, 5A/6A genotype carriers had a significantly longer QTc duration by 9.50 ms (95% CI: 3.48-15.52, p = 0.002), whilst 6A/6A genotype carriers had an even longer QTc duration by 12.19 ms (95% CI: 5.04-19.34, p = 0.001). We found an association between MMP-3 5A/6A polymorphisms and QTc, independent of adjustments for age, gender, alcohol consumption, smoking status, body mass index and blood pressure. |
