Early Measurement of Blood sST2 Is a Good Predictor of Death and Poor Outcomes in Patients Admitted for COVID-19 Infection.

Autor: Sánchez-Marteles M; Department of Internal Medicine, Hospital Clínico Universitario, Lozano Blesa, 50009 Zaragoza, Spain.; Aragon Health Research Institute (IIS Aragón), 50009 Zaragoza, Spain., Rubio-Gracia J; Department of Internal Medicine, Hospital Clínico Universitario, Lozano Blesa, 50009 Zaragoza, Spain.; Aragon Health Research Institute (IIS Aragón), 50009 Zaragoza, Spain., Peña-Fresneda N; Aragon Health Research Institute (IIS Aragón), 50009 Zaragoza, Spain.; Facultad de Medicina, University of Zaragoza, 50009 Zaragoza, Spain., Garcés-Horna V; Department of Internal Medicine, Hospital Clínico Universitario, Lozano Blesa, 50009 Zaragoza, Spain.; Aragon Health Research Institute (IIS Aragón), 50009 Zaragoza, Spain., Gracia-Tello B; Department of Internal Medicine, Hospital Clínico Universitario, Lozano Blesa, 50009 Zaragoza, Spain.; Aragon Health Research Institute (IIS Aragón), 50009 Zaragoza, Spain., Martínez-Lostao L; Aragon Health Research Institute (IIS Aragón), 50009 Zaragoza, Spain.; Facultad de Medicina, University of Zaragoza, 50009 Zaragoza, Spain.; Department of Immunology, Hospital Clínico Universitario, Lozano Blesa, 50009 Zaragoza, Spain., Crespo-Aznárez S; Department of Internal Medicine, Hospital Clínico Universitario, Lozano Blesa, 50009 Zaragoza, Spain., Pérez-Calvo JI; Department of Internal Medicine, Hospital Clínico Universitario, Lozano Blesa, 50009 Zaragoza, Spain.; Aragon Health Research Institute (IIS Aragón), 50009 Zaragoza, Spain.; Facultad de Medicina, University of Zaragoza, 50009 Zaragoza, Spain., Giménez-López I; Aragon Health Research Institute (IIS Aragón), 50009 Zaragoza, Spain.; Facultad de Medicina, University of Zaragoza, 50009 Zaragoza, Spain.; Instituto Aragonés de Ciencias de la Salud (IACS), 50009 Zaragoza, Spain.
Jazyk: angličtina
Zdroj: Journal of clinical medicine [J Clin Med] 2021 Aug 11; Vol. 10 (16). Date of Electronic Publication: 2021 Aug 11.
DOI: 10.3390/jcm10163534
Abstrakt: Although several biomarkers have shown correlation to prognosis in COVID-19 patients, their clinical value is limited because of lack of specificity, suboptimal sensibility or poor dynamic behavior. We hypothesized that circulating soluble ST2 (sST2) could be associated to a worse outcome in COVID-19. In total, 152 patients admitted for confirmed COVID-19 were included in a prospective non-interventional, observational study. Blood samples were drawn at admission, 48-72 h later and at discharge. sST2 concentrations and routine blood laboratory were analyzed. Primary endpoints were admission at intensive care unit (ICU) and mortality. Median age was 57.5 years [Standard Deviation (SD: 12.8)], 60.4% males. 10% of patients ( n = 15) were derived to ICU and/or died during admission. Median (IQR) sST2 serum concentration (ng/mL) rose to 53.1 (30.9) at admission, peaked at 48-72 h (79.5(64)) and returned to admission levels at discharge (44.9[36.7]). A concentration of sST2 above 58.9 ng/mL was identified patients progressing to ICU admission or death. Results remained significant after multivariable analysis. The area under the receiver operating characteristics curve (AUC) of sST2 for endpoints was 0.776 ( p = 0.001). In patients admitted for COVID-19 infection, early measurement of sST2 was able to identify patients at risk of severe complications or death.
Databáze: MEDLINE
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