| Autor: |
Idda ML; Institute of Genetics and Biomedical research, 07100 Sassari, Italy., Campesi I; Department of Biomedical Sciences, University of Sassari, 07100 Sassari, Italy., Fiorito G; Department of Biomedical Sciences, University of Sassari, 07100 Sassari, Italy.; Unit of Environmental Epidemiology, School of Public Health, Imperial College, London SW7 2AZ, UK., Vecchietti A; Department of Biomedical Sciences, University of Sassari, 07100 Sassari, Italy., Urru SAM; Hospital Pharmacy Unit, Trento General Hospital, Autonomous Province of Trento, 38122 Trento, Italy.; Department of Chemistry and Pharmacy, School of Hospital Pharmacy, University of Sassari, 07100 Sassari, Italy., Solinas MG; Department of Biomedical Sciences, University of Sassari, 07100 Sassari, Italy., Franconi F; National Laboratory of Pharmacology and Gender medicine, National Institute of Biostructure and Biosystems, 00136 Rome, Italy., Floris M; Institute of Genetics and Biomedical research, 07100 Sassari, Italy.; Department of Biomedical Sciences, University of Sassari, 07100 Sassari, Italy. |
| Abstrakt: |
Individual response to drugs is highly variable and largely influenced by genetic variants and gene-expression profiles. In addition, it has been shown that response to drugs is strongly sex-dependent, both in terms of efficacy and toxicity. To expand current knowledge on sex differences in the expression of genes relevant for drug response, we generated a catalogue of differentially expressed human transcripts encoded by 289 genes in 41 human tissues from 838 adult individuals of the Genotype-Tissue Expression project (GTEx, v8 release) and focused our analysis on relevant transcripts implicated in drug response. We detected significant sex-differentiated expression of 99 transcripts encoded by 59 genes in the tissues most relevant for human pharmacology (liver, lung, kidney, small intestine terminal ileum, skin not sun-exposed, and whole blood). Among them, as expected, we confirmed significant differences in the expression of transcripts encoded by the cytochromes in the liver, CYP2B6, CYP3A7, CYP3A5, and CYP1A1. Our systematic investigation on differences between male and female in the expression of drug response-related genes, reinforce the need to overcome the sex bias of clinical trials. |
