| Autor: |
Prakash P; Department of Botany, Periyar University, Periyar Palkalai Nagar, Salem 636011, India., Kumari N; Department of Radiology, Seoul National University Hospital, Seoul National University College of Medicine, Seoul 03080, Korea., Gayathiri E; Department of Plant Biology and Plant Biotechnology, Guru Nanak College, Chennai 600042, India., Selvam K; Department of Botany, Periyar University, Periyar Palkalai Nagar, Salem 636011, India., Ragunathan MG; Department of Advanced Zoology and Biotechnology, Guru Nanak College, Chennai 600042, India., Chandrasekaran M; Department of Food Science and Biotechnology, Sejong University, Gwangjin-gu, Seoul 05006, Korea., Al-Dosary MA; Department of Botany and Microbiology, College of Science, King Saud University, Riyadh 11451, Saudi Arabia., Hatamleh AA; Department of Botany and Microbiology, College of Science, King Saud University, Riyadh 11451, Saudi Arabia., Nadda AK; Department of Biotechnology and Bioinformatics, Jaypee University of Information Technology, Waknaghat, Solan 173234, India., Kumar M; Department of Life Science, College of Life Science and Biotechnology, Dongguk University, Seoul 10326, Korea. |
| Jazyk: |
angličtina |
| Zdroj: |
Antioxidants (Basel, Switzerland) [Antioxidants (Basel)] 2021 Aug 18; Vol. 10 (8). Date of Electronic Publication: 2021 Aug 18. |
| DOI: |
10.3390/antiox10081307 |
| Abstrakt: |
Plant-derived antioxidants are a large group of natural products with the capacity to reduce radical-scavenging. Due to their potent therapeutic and preventive actions, these compounds receive a lot of attention from scientists, particularly pharmacologists. The pharmacological activities of the Azima tetracantha Lam. ( AT ) plant, belonging to the Salvadoraceae family, reported here justifies its traditional use in treating several diseases or disorders. This study aims to look at the propensity of certain plant compounds found in natural AT plant extracts that might play a critical role as a secondary metabolite in cervical cancer treatment. There is a shortage of information on the plant's phytochemical and biological characteristics. Methanol (MeOH) solvent extracts of the dried AT plant were screened phytochemically. Its aqueous extract was tested for antioxidant, antiseptic, anti-inflammatory, and anticancerous properties. Absorption Distribution Metabolism and Excretion (ADME/T), Docking, and HPLC were also performed. In clinical treatment, the plant shown no adverse effects. The antioxidant activity was evaluated and showed the highest concentration at 150 µg/mL (63.50%). MeOH leaf extract of AT exhibited the highest and best inhibitory activity against Staphylococcus aureus (15.3 mm/1000) and displayed a high antiseptic potential. At a 200 µg/mL concentration, MeOH leaves-extract inhibited red blood cells (RBC) hemolysis by 66.56 ± 0.40, compared with 62.33 ± 0.40 from the standard. Albumin's ability to suppress protein denaturation ranged from 16.75 ± 0.65 to 62.35 ± 0.20 inhibitions in this test, providing even more support for its favorable anti-inflammatory properties. The ADME/T studies were considered for a potential cancer drug molecule, and one of our compounds from MeOH extract fills the ADME and toxicity parameters. The forms of compound 4 showed a strong hydrogen-bonding interaction with the vital amino acids (ASN923, THR410, LEU840TRY927, PHE921, and GLY922). A total of 90% of cell inhibition was observed when HeLa cell lines were treated with 300 µg/mL of compound 4 (7-acetyl-3a 1 -methyl- 4,14-dioxo-1,2,3a,3a 1 ,4,5,5a,6,8a,9b,10,11,11a-tetradecahydro-2,5a epoxy5,6a (methanooxymethano)phenaleno[1',9':5,6,7]indeno[1,7a- b ]oxiren-2-yl acetate). The polyphenol compounds demonstrated significant advances in anticancer drug properties, and it could lead to activation of cancer cell apoptosis. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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