| Autor: |
Hay JL; Department of Psychiatry and Behavioral Sciences, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA., Kaphingst KA; Cancer Communication Research, Huntsman Cancer Center, University of Utah, Salt Lake City, UT 84112, USA., Buller D; Klein Buendel, Inc., Golden, CO 80401, USA., Schofield E; Department of Psychiatry and Behavioral Sciences, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA., Meyer White K; New Mexico VA Health System, Veterans Health Administration, Albuquerque, NM 87108, USA., Sussman A; Department of Family and Community Medicine, University of New Mexico, Albuquerque, NM 87102, USA., Guest D; University of New Mexico Comprehensive Cancer Center, Albuquerque, NM 87102, USA., Dailey YT; University of New Mexico Comprehensive Cancer Center, Albuquerque, NM 87102, USA., Robers E; University of New Mexico Comprehensive Cancer Center, Albuquerque, NM 87102, USA., Schwartz MR; University of New Mexico Comprehensive Cancer Center, Albuquerque, NM 87102, USA., Li Y; Department of Psychiatry and Behavioral Sciences, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA., Hunley K; Department of Anthropology, University of New Mexico, Albuquerque, NM 87102, USA., Berwick M; Department of Internal Medicine, University of New Mexico, Albuquerque, NM 87102, USA.; Department of Dermatology, University of New Mexico, Albuquerque, NM 87102, USA. |
| Abstrakt: |
Public availability of genetic information is increasing; thus, efforts to improve diversity in basic and translational research in genomics is a top priority. Given the increasing U.S. incidence and mortality of melanoma, and the prevalence of common melanocortin-1 receptor ( MC1R) gene melanoma risk variants in the general population, we examined genomic testing of MC1R for skin cancer risk in a randomized controlled trial in Albuquerque, New Mexico primary care. Participants were 48% Hispanic and were randomized 5:1 to a MC1R test invitation or usual care. We assessed 3 month sun protection, skin cancer screening, and skin cancer worry outcomes associated with testing, and key effect moderators (e.g., cancer risk perceptions, and skin cancer risk factors). Our findings indicate that the primary outcomes were unchanged by the MC1R test offer, test acceptance, and level of risk feedback. Moderator analyses showed that those with lower risk perception, and those with skin that readily tans, significantly increased their sun protection in response to higher than average risk feedback. Risk feedback did not prompt cancer worry, and average risk feedback did not erode existing sun protection. This study paves the way for the development of tailored strategies to address low skin cancer risk awareness in this understudied context of public health genomics. |
