Survival and Disease Recurrence in Patients with Duodenal Neuroendocrine Tumours-A Single Centre Cohort.

Autor: Folkestad O; Department of Gastrointestinal Surgery, St. Olav's Hospital, Trondheim University Hospital, 7030 Trondheim, Norway.; Department of Gastrointestinal Surgery, Vestfold Hospital, 3103 Tønsberg, Norway., Wasmuth HH; Department of Clinical and Molecular Medicine, Faculty of Medicine and Health Sciences, Norwegian University of Science and Technology (NTNU), 7030 Trondheim, Norway., Mjønes P; Department of Clinical and Molecular Medicine, Faculty of Medicine and Health Sciences, Norwegian University of Science and Technology (NTNU), 7030 Trondheim, Norway.; Department of Pathology, St. Olav's Hospital, Trondheim University Hospital, 7030 Trondheim, Norway., Fougner R; Department of Radiology, St. Olav's Hospital, Trondheim University Hospital, 7030 Trondheim, Norway., Hauso Ø; Department of Clinical and Molecular Medicine, Faculty of Medicine and Health Sciences, Norwegian University of Science and Technology (NTNU), 7030 Trondheim, Norway.; Department of Gastroenterology and Hepatology, St. Olav's Hospital, Trondheim University Hospital, 7030 Trondheim, Norway., Fossmark R; Department of Clinical and Molecular Medicine, Faculty of Medicine and Health Sciences, Norwegian University of Science and Technology (NTNU), 7030 Trondheim, Norway.; Department of Gastroenterology and Hepatology, St. Olav's Hospital, Trondheim University Hospital, 7030 Trondheim, Norway.
Jazyk: angličtina
Zdroj: Cancers [Cancers (Basel)] 2021 Aug 06; Vol. 13 (16). Date of Electronic Publication: 2021 Aug 06.
DOI: 10.3390/cancers13163985
Abstrakt: Background: Duodenal neuroendocrine tumours (D-NETs) are rare but increasingly diagnosed. This study aimed to assess the overall survival and recurrence rate among patients treated for D-NETs.
Methods: Patients with D-NETs were retrospectively reviewed with a median follow-up time of 4.8 years (range 0.0-17.2 years).
Results: A total of 32 patients with median age 68.0 years were identified. Fifteen patients underwent surgery while ten patients underwent endoscopic treatment. Mean estimated overall survival for the entire population was 12.1 years (95% CI 9.5-14.7 years), while 5-year overall survival was 81.3%. Tumour grade G1 was associated with longer mean estimated survival compared to G2 tumours (13.2 years versus 4.4 years, p = 0.010). None of the 23 patients who underwent presumed radical endoscopic or surgical resection had disease recurrence during follow-up. Tumours <10 mm could be treated endoscopically whereas a high proportion of patients with tumours 10-20 mm should be considered for surgery.
Conclusion: Patients with D-NETs had long overall survival, and mortality was more influenced by other diseases. Both endoscopic and surgical resections were effective as no recurrences were diagnosed during follow-up.
Databáze: MEDLINE
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