Induced sputum abnormalities in gas station attendants.

Autor: da Silva THG; Internal Medicine Department. Medical School of Ribeirão Preto, University of São Paulo, Avenida Bandeirantes 3900, Ribeirao Preto, SP, 14048-900, Brazil., Gastaldi AC; Department of Health Sciences, Medical School of Ribeirão Preto, University of São Paulo, Ribeirao Preto, SP, Brazil., Santos MK; Department of Medical Imaging, Hematology and Oncology, Medical School of Ribeirão Preto, University of São Paulo, Ribeirao Preto, SP, Brazil., de Martinis BS; Department of Chemistry, Faculty of Philosophy, Science and Languages of Ribeirão Preto, University of São Paulo, Ribeirao Preto, SP, Brazil., Baddini-Martinez J; Internal Medicine Department. Medical School of Ribeirão Preto, University of São Paulo, Avenida Bandeirantes 3900, Ribeirao Preto, SP, 14048-900, Brazil. baddini@fmrp.usp.br.
Jazyk: angličtina
Zdroj: International archives of occupational and environmental health [Int Arch Occup Environ Health] 2022 Mar; Vol. 95 (2), pp. 341-349. Date of Electronic Publication: 2021 Aug 25.
DOI: 10.1007/s00420-021-01755-2
Abstrakt: Purpose: To investigate inflammatory changes in the induced sputum (IS) of gas station attendants (GSAs) at risk of exposure to fuel vapors through inhalation and susceptible to respiratory complaints and impaired lung function.
Methods: Hypertonic saline-IS was collected from 52 GSAs who had never smoked (42 men, age = 35.9 ± 8.9 years) and had no known comorbidities. A group of 22 non-smokers (11 men, age = 30.5 ± 5.1 years) selected from the University staff served as control. The GSAs answered a questionnaire and underwent spirometry and chest tomography. A total of 15 inflammatory biomarkers associated with inflammation, including cytokines, chemokines, and mediators of immunological response, were also measured.
Results: The most common symptoms of GSAs were coughing (42.3%) and dyspnea (59.6%) based on the New York Heart Association (NYHA; Class II) classification. Significant elevations (p < 0.05) in forced vital capacity and forced expiratory volume within the first second were observed in the GSAs relative to those in the controls (GSA vs. control: 99 ± 12% vs. 90 ± 9% and 94 ± 11% vs. 87 ± 10%, respectively). The GSAs had a lower percentage of IS lymphocytes than that in the control group (4.5 ± 5.7% vs. 7.7 ± 9.8%). The GSAs also had significantly lower concentrations of IL-4, IL-5, IL-10, IL-12 P70 , IFN-γ, and MIP-1α, but IL-3 levels were higher. No differences were observed in the airway thickness and the amount of emphysema between the GSAs and the controls.
Conclusion: Despite normal lung function and absence of abnormalities on HRCT, GSAs have a higher frequency of respiratory complaints, with evidence of impairment of lymphocytic activity in the airways.
(© 2021. The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature.)
Databáze: MEDLINE
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