The prefrontal cortex and neurosurgical treatment for intractable OCD.

Autor: Rasmussen SA; Department of Psychiatry and Human Behavior, Alpert School of Medicine, Brown University, Providence, RI, USA. Steven_Rasmussen@Brown.edu.; Carney Brain Science Institute, Brown University, Providence, RI, USA. Steven_Rasmussen@Brown.edu., Goodman WK; Menninger Department of Psychiatry and Behavioral Sciences, Baylor College of Medicine, Houston, TX, USA.
Jazyk: angličtina
Zdroj: Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology [Neuropsychopharmacology] 2022 Jan; Vol. 47 (1), pp. 349-360. Date of Electronic Publication: 2021 Aug 25.
DOI: 10.1038/s41386-021-01149-5
Abstrakt: Over the past two decades, circuit-based neurosurgical procedures have gained increasing acceptance as a safe and efficacious approach to the treatment of the intractable obsessive-compulsive disorder (OCD). Lesions and deep brain stimulation (DBS) of the longitudinal corticofugal white matter tracts connecting the prefrontal cortex with the striatum, thalamus, subthalamic nucleus (STN), and brainstem implicate orbitofrontal, medial prefrontal, frontopolar, and ventrolateral cortical networks in the symptoms underlying OCD. The highly parallel distributed nature of these networks may explain the relative lack of adverse effects observed following surgery. Additional pre-post studies of cognitive tasks in more surgical patients are needed to confirm the role of these networks in OCD and to define therapeutic responses to surgical intervention.
(© 2021. The Author(s), under exclusive licence to American College of Neuropsychopharmacology.)
Databáze: MEDLINE
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