Opposing roles for striatonigral and striatopallidal neurons in dorsolateral striatum in consolidating new instrumental actions.

Autor: Smith ACW; Nash Family Department of Neuroscience, Icahn School of Medicine at Mount Sinai, New York, NY, USA., Jonkman S; Nash Family Department of Neuroscience, Icahn School of Medicine at Mount Sinai, New York, NY, USA., Difeliceantonio AG; Nash Family Department of Neuroscience, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Department of Human Nutrition, Foods and Exercise, College of Agriculture and Life Sciences and Center for Transformative Research on Health Behaviors, Fralin Biomedical Research Institute, Virginia Tech, VA, USA., O'Connor RM; Nash Family Department of Neuroscience, Icahn School of Medicine at Mount Sinai, New York, NY, USA., Ghoshal S; Nash Family Department of Neuroscience, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Hunter College, City University of New York, New York, NY, USA., Romano MF; Department of Computational Neuroscience, Boston University, Boston, MA, USA., Everitt BJ; Department of Psychology, University of Cambridge, Cambridge, UK., Kenny PJ; Nash Family Department of Neuroscience, Icahn School of Medicine at Mount Sinai, New York, NY, USA. paul.kenny@mssm.edu.
Jazyk: angličtina
Zdroj: Nature communications [Nat Commun] 2021 Aug 25; Vol. 12 (1), pp. 5121. Date of Electronic Publication: 2021 Aug 25.
DOI: 10.1038/s41467-021-25460-3
Abstrakt: Comparatively little is known about how new instrumental actions are encoded in the brain. Using whole-brain c-Fos mapping, we show that neural activity is increased in the anterior dorsolateral striatum (aDLS) of mice that successfully learn a new lever-press response to earn food rewards. Post-learning chemogenetic inhibition of aDLS disrupts consolidation of the new instrumental response. Similarly, post-learning infusion of the protein synthesis inhibitor anisomycin into the aDLS disrupts consolidation of the new response. Activity of D1 receptor-expressing medium spiny neurons (D1-MSNs) increases and D2-MSNs activity decreases in the aDLS during consolidation. Chemogenetic inhibition of D1-MSNs in aDLS disrupts the consolidation process whereas D2-MSN inhibition strengthens consolidation but blocks the expression of previously learned habit-like responses. These findings suggest that D1-MSNs in the aDLS encode new instrumental actions whereas D2-MSNs oppose this new learning and instead promote expression of habitual actions.
(© 2021. The Author(s).)
Databáze: MEDLINE
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