Tractography dissection variability: What happens when 42 groups dissect 14 white matter bundles on the same dataset?

Autor: Schilling KG; Department of Radiology and Radiological Sciences, Vanderbilt University Medical Center, Nashville, TN, United States. Electronic address: kurt.g.schilling.1@vumc.org., Rheault F; SCIL, Université de Sherbrooke, Québec, Canada., Petit L; Groupe dImagerie Neurofonctionnelle, Institut Des Maladies Neurodegeneratives, CNRS, CEA University of Bordeaux, Bordeaux, France., Hansen CB; Department of Electrical Engineering and Computer Science, Vanderbilt University, Nashville, TN, United States., Nath V; Department of Electrical Engineering and Computer Science, Vanderbilt University, Nashville, TN, United States., Yeh FC; Department of Neurological Surgery, University of Pittsburgh, Pittsburgh, PA, United States., Girard G; CIBM Center for BioMedical Imaging, Lausanne, Switzerland., Barakovic M; Translational Imaging in Neurology (ThINK), Department of Medicine and Biomedical Engineering, University Hospital and University of Basel, Basel, Switzerland., Rafael-Patino J; Signal Processing Lab (LTS5), École Polytechnique Fédérale de Lausanne, Lausanne, Switzerland., Yu T; Signal Processing Lab (LTS5), École Polytechnique Fédérale de Lausanne, Lausanne, Switzerland., Fischi-Gomez E; Signal Processing Lab (LTS5), École Polytechnique Fédérale de Lausanne, Lausanne, Switzerland., Pizzolato M; Department of Applied Mathematics and Computer Science, Technical University of Denmark, Kongens Lyngby, Denmark., Ocampo-Pineda M; Department of Computer Science, University of Verona, Italy., Schiavi S; Department of Computer Science, University of Verona, Italy., Canales-Rodríguez EJ; Signal Processing Lab (LTS5), École Polytechnique Fédérale de Lausanne, Lausanne, Switzerland., Daducci A; Department of Computer Science, University of Verona, Italy., Granziera C; Translational Imaging in Neurology (ThINK), Department of Medicine and Biomedical Engineering, University Hospital and University of Basel, Basel, Switzerland., Innocenti G; Department of Neuroscience, Karolinska Institutet, Stockholm, Sweden., Thiran JP; Signal Processing Lab (LTS5), École Polytechnique Fédérale de Lausanne, Lausanne, Switzerland., Mancini L; Lysholm Department of Neuroradiology, National Hospital for Neurology & Neurosurgery, UCL Hospitals NHS Foundation Trust, London, United Kingdom., Wastling S; Lysholm Department of Neuroradiology, National Hospital for Neurology & Neurosurgery, UCL Hospitals NHS Foundation Trust, London, United Kingdom., Cocozza S; Department of Advanced Biomedical Sciences, University 'Federico II', Naples, Italy., Petracca M; Department of Neurosciences and Reproductive and Odontostomatological Sciences, University 'Federico II', Naples, Italy., Pontillo G; Department of Advanced Biomedical Sciences, University 'Federico II', Naples, Italy., Mancini M; Department of Neuroscience, Brighton and Sussex Medical School, University of Sussex, Brighton, United Kingdom., Vos SB; Centre for Medical Image Computing, University College London, London, United Kingdom., Vakharia VN; Department of Clinical and Experimental Epilepsy, University College London, London, United Kingdom., Duncan JS; Epilepsy Society MRI Unit, Chalfont St Peter, United Kingdom., Melero H; Departamento de Psicobiología y Metodología en Ciencias del Comportamiento - Universidad Complutense de Madrid, Spain Laboratorio de Análisis de Imagen Médica y Biometría (LAIMBIO), Universidad Rey Juan Carlos, Madrid, Spain., Manzanedo L; Facultad de Ciencias de la Salud, Universidad Rey Juan Carlos, Madrid, Spain., Sanz-Morales E; Laboratorio de Análisis de Imagen Médica y Biometría (LAIMBIO), Universidad Rey Juan Carlos, Madrid, Spain., Peña-Melián Á; Departamento de Anatomía, Facultad de Medicina, Universidad Complutense de Madrid, Madrid, Spain., Calamante F; Sydney Imaging and School of Biomedical Engineering, The University of Sydney, Sydney, Australia., Attyé A; School of Biomedical Engineering, The University of Sydney, Sydney, Australia., Cabeen RP; Laboratory of Neuro Imaging, Stevens Neuroimaging and Informatics Institute, Keck School of Medicine of USC, University of Southern California, Los Angeles, CA, United States., Korobova L; Center for Integrative Connectomics, Stevens Neuroimaging and Informatics Institute, Keck School of Medicine of USC, University of Southern California, Los Angeles, CA, United States., Toga AW; Laboratory of Neuro Imaging, Stevens Neuroimaging and Informatics Institute, Keck School of Medicine of USC, University of Southern California, Los Angeles, CA, United States., Vijayakumari AA; Department of Radiology, University of Pennsylvania, Philadelphia, PA, United States., Parker D; Department of Radiology, University of Pennsylvania, Philadelphia, PA, United States., Verma R; Department of Radiology, University of Pennsylvania, Philadelphia, PA, United States., Radwan A; KU Leuven, Department of Imaging and Pathology, Translational MRI, B-3000, Leuven, Belgium., Sunaert S; KU Leuven, Department of Imaging and Pathology, Translational MRI, B-3000, Leuven, Belgium., Emsell L; KU Leuven, Department of Imaging and Pathology, Translational MRI, B-3000, Leuven, Belgium., De Luca A; PROVIDI Lab, UMC Utrecht, The Netherlands., Leemans A; PROVIDI Lab, UMC Utrecht, The Netherlands., Bajada CJ; Department of Physiology and Biochemistry, Faculty of Medicine and Surgery, University of Malta, Malta., Haroon H; Division of Neuroscience & Experimental Psychology, Faculty of Biology, Medicine and Health, The University of Manchester, Manchester Academic Health Science Centre, Manchester, United Kingdom., Azadbakht H; AINOSTICS Limited, London, United Kingdom., Chamberland M; Cardiff University Brain Research Imaging Centre (CUBRIC), Cardiff University, Cardiff, United Kingdom., Genc S; Cardiff University Brain Research Imaging Centre (CUBRIC), Cardiff University, Cardiff, United Kingdom., Tax CMW; Cardiff University Brain Research Imaging Centre (CUBRIC), Cardiff University, Cardiff, United Kingdom., Yeh PH; National Intrepid Center of Excellence, Walter Reed National Military Medical Center, Bethesda, MD, USA., Srikanchana R; National Intrepid Center of Excellence, Walter Reed National Military Medical Center, Bethesda, MD, USA., Mcknight CD; Department of Radiology and Radiological Sciences, Vanderbilt University Medical Center, Nashville, TN, United States., Yang JY; Department of Neurosurgery, Neuroscience Advanced Clinical Imaging Suite (NACIS), Royal Children's Hospital, Parkville, Melbourne, Australia., Chen J; Developmental Imaging, Murdoch Children's Research Institute, Melbourne, Australia., Kelly CE; Victorian Infant Brain Studies, Murdoch Children's Research Institute, Melbourne, Australia., Yeh CH; Institute for Radiological Research, Chang Gung University & Chang Gung Memorial Hospital, Taoyuan, Taiwan., Cochereau J; Poitiers University Hospital, France., Maller JJ; MRI Clinical Science Specialist, General Electric Healthcare, Australia., Welton T; National Neuroscience Institute, Singapore., Almairac F; Neurosurgery department, Hôpital Pasteur, University Hospital of Nice, Côte d'Azur University, France., Seunarine KK; Developmental Imaging and Biophysics Section, UCL GOS Institute of Child Health, London., Clark CA; Developmental Imaging and Biophysics Section, UCL GOS Institute of Child Health, London., Zhang F; Brigham & Women's Hospital and Harvard Medical School, Boston, Massachusetts, USA., Makris N; Brigham & Women's Hospital and Harvard Medical School, Boston, Massachusetts, USA., Golby A; Brigham & Women's Hospital and Harvard Medical School, Boston, Massachusetts, USA., Rathi Y; Brigham & Women's Hospital and Harvard Medical School, Boston, Massachusetts, USA., O'Donnell LJ; Brigham & Women's Hospital and Harvard Medical School, Boston, Massachusetts, USA., Xia Y; University of Southern California, Keck School of Medicine, Neuroimaging and Informatics Institute, Los Angeles, California, United States., Aydogan DB; Department of Neuroscience and Biomedical Engineering, Aalto University School of Science, Espoo, Finland., Shi Y; University of Southern California, Keck School of Medicine, Neuroimaging and Informatics Institute, Los Angeles, California, United States., Fernandes FG; UMC Utrecht Brain Center, Department of Neurology&Neurosurgery, Utrecht, the Netherlands., Raemaekers M; UMC Utrecht Brain Center, Department of Neurology&Neurosurgery, Utrecht, the Netherlands., Warrington S; Sir Peter Mansfield Imaging Centre, School of Medicine, University of Nottingham, UK., Michielse S; Department of Neurosurgery, School for Mental Health and Neuroscience, Maastricht University., Ramírez-Manzanares A; Centro de Investigación en Matemáticas A.C. (CIMAT), Guanajuato, Mexico., Concha L; Universidad Nacional Autonoma de Mexico, Institute of Neurobiology, Mexico City, Mexico., Aranda R; Centro de Investigación Científica y de Educación Superior de Ensenada (CICESE-UT3), Cátedras-CONACyT, Ensenada, Mexico., Meraz MR; Centro de Investigación en Matemáticas A.C. (CIMAT), Guanajuato, Mexico., Lerma-Usabiaga G; Department of Psychology, Stanford University, Stanford, California, USA., Roitman L; Department of Psychology, Stanford University, Stanford, California, USA., Fekonja LS; Department of Neurosurgery, Charité - Universitätsmedizin Berlin, Berlin, Germany., Calarco N; Kimel Family Translational Imaging-Genetics Laboratory, Research Imaging Centre, Centre for Addiction and Mental Health, Toronto, Ontario., Joseph M; Kimel Family Translational Imaging-Genetics Laboratory, Research Imaging Centre, Centre for Addiction and Mental Health, Toronto, Ontario., Nakua H; Kimel Family Translational Imaging-Genetics Laboratory, Research Imaging Centre, Centre for Addiction and Mental Health, Toronto, Ontario., Voineskos AN; Kimel Family Translational Imaging-Genetics Laboratory, Research Imaging Centre, Centre for Addiction and Mental Health, Toronto, Ontario., Karan P; SCIL, Université de Sherbrooke, Québec, Canada., Grenier G; SCIL, Université de Sherbrooke, Québec, Canada., Legarreta JH; SCIL, Université de Sherbrooke, Québec, Canada., Adluru N; University of Wisconsin-Madison, Madison, WI, USA., Nair VA; University of Wisconsin-Madison, Madison, WI, USA., Prabhakaran V; University of Wisconsin-Madison, Madison, WI, USA., Alexander AL; University of Wisconsin-Madison, Madison, WI, USA., Kamagata K; Department of Radiology, Juntendo University Graduate School of Medicine, Tokyo Japan., Saito Y; Department of Radiology, Juntendo University Graduate School of Medicine, Tokyo Japan., Uchida W; Department of Radiology, Juntendo University Graduate School of Medicine, Tokyo Japan., Andica C; Department of Radiology, Juntendo University Graduate School of Medicine, Tokyo Japan., Abe M; Department of Radiology, Juntendo University Graduate School of Medicine, Tokyo Japan., Bayrak RG; Department of Electrical Engineering and Computer Science, Vanderbilt University, Nashville, TN, United States., Wheeler-Kingshott CAMG; NMR Research Unit, Queen Square MS Centre, Department of Neuroinflammation, UCL Queen Square Institute of Neurology, Faculty of Brain Sciences, University College London, London, United Kingdom., D'Angelo E; Department of Brain and Behavioral Sciences, University of Pavia, Italy., Palesi F; Department of Brain and Behavioral Sciences, University of Pavia, Italy., Savini G; Brain MRI 3T Research Center, IRCCS Mondino Foundation, Pavia, Italy., Rolandi N; Department of Brain and Behavioral Sciences, University of Pavia, Italy., Guevara P; Universidad de Concepción, Faculty of Engineering, Concepción, Chile., Houenou J; Université Paris-Saclay, CEA, CNRS, Neurospin, Gif-sur-Yvette, France., López-López N; Universidad de Concepción, Faculty of Engineering, Concepción, Chile., Mangin JF; Université Paris-Saclay, CEA, CNRS, Neurospin, Gif-sur-Yvette, France., Poupon C; Université Paris-Saclay, CEA, CNRS, Neurospin, Gif-sur-Yvette, France., Román C; Universidad de Concepción, Faculty of Engineering, Concepción, Chile., Vázquez A; Universidad de Concepción, Faculty of Engineering, Concepción, Chile., Maffei C; Athinoula A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts, USA., Arantes M; Department of Biomedicine, Unit of Anatomy, Faculty of Medicine of the University of Porto, Al. Professor Hernâni Monteiro, Porto, Portugal., Andrade JP; Department of Biomedicine, Unit of Anatomy, Faculty of Medicine of the University of Porto, Al. Professor Hernâni Monteiro, Porto, Portugal., Silva SM; Department of Biomedicine, Unit of Anatomy, Faculty of Medicine of the University of Porto, Al. Professor Hernâni Monteiro, Porto, Portugal., Calhoun VD; Tri-institutional Center for Translational Research in Neuroimaging and Data Science (TReNDS), Georgia State University, Georgia Institute of Technology, Emory University, Atlanta, GA 30303, United States., Caverzasi E; Neurology Department UCSF Weill Institute for Neurosciences, University of California, San Francisco., Sacco S; Neurology Department UCSF Weill Institute for Neurosciences, University of California, San Francisco., Lauricella M; Memory and Aging Center. UCSF Weill Institute for Neurosciences, University of California, San Francisco, USA., Pestilli F; Department of Psychology, The University of Texas at Austin, TX 78731, USA., Bullock D; Department of Psychology, The University of Texas at Austin, TX 78731, USA., Zhan Y; Brain Cognition and Brain Disease Institute, Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences, Shenzhen, 518055, China., Brignoni-Perez E; Developmental-Behavioral Pediatrics Division, Department of Pediatrics, Stanford School of Medicine, Stanford, CA, United States., Lebel C; Department of Radiology, University of Calgary, 2500 University Drive NW, Calgary, AB, Canada, T2N 1N4., Reynolds JE; Department of Radiology, University of Calgary, 2500 University Drive NW, Calgary, AB, Canada, T2N 1N4., Nestrasil I; Division of Clinical Behavioral Neuroscience, Department of Pediatrics, University of Minnesota, Minneapolis, MN, USA., Labounek R; Division of Clinical Behavioral Neuroscience, Department of Pediatrics, University of Minnesota, Minneapolis, MN, USA., Lenglet C; Center for Magnetic Resonance Research, Department of Radiology, University of Minnesota, Minneapolis, MN, USA., Paulson A; Division of Clinical Behavioral Neuroscience, Department of Pediatrics, University of Minnesota, Minneapolis, MN, USA., Aulicka S; Department of Paediatric Neurology, University Hospital and Medicine Faculty, Masaryk University, Brno, Czech Republic., Heilbronner SR; Department of Neuroscience, University of Minnesota, Minneapolis, MN, USA., Heuer K; Center for Research and Interdisciplinarity (CRI), INSERM U1284, Université de Paris, Paris, France., Chandio BQ; Department of Intelligent Systems Engineering, Indiana University, Bloomington, IN, USA., Guaje J; Department of Intelligent Systems Engineering, Indiana University, Bloomington, IN, USA., Tang W; Department of Computer Science, Indiana University, Bloomington, IN, USA., Garyfallidis E; Department of Intelligent Systems Engineering, Indiana University, Bloomington, IN, USA., Raja R; University of Arkansas for Medical Sciences, Little Rock, AR, USA., Anderson AW; Department of Radiology and Radiological Sciences, Vanderbilt University Medical Center, Nashville, TN, USA., Landman BA; Department of Electrical Engineering and Computer Science, Vanderbilt University, Nashville, TN, United States., Descoteaux M; SCIL, Université de Sherbrooke, Québec, Canada.
Jazyk: angličtina
Zdroj: NeuroImage [Neuroimage] 2021 Nov; Vol. 243, pp. 118502. Date of Electronic Publication: 2021 Aug 22.
DOI: 10.1016/j.neuroimage.2021.118502
Abstrakt: White matter bundle segmentation using diffusion MRI fiber tractography has become the method of choice to identify white matter fiber pathways in vivo in human brains. However, like other analyses of complex data, there is considerable variability in segmentation protocols and techniques. This can result in different reconstructions of the same intended white matter pathways, which directly affects tractography results, quantification, and interpretation. In this study, we aim to evaluate and quantify the variability that arises from different protocols for bundle segmentation. Through an open call to users of fiber tractography, including anatomists, clinicians, and algorithm developers, 42 independent teams were given processed sets of human whole-brain streamlines and asked to segment 14 white matter fascicles on six subjects. In total, we received 57 different bundle segmentation protocols, which enabled detailed volume-based and streamline-based analyses of agreement and disagreement among protocols for each fiber pathway. Results show that even when given the exact same sets of underlying streamlines, the variability across protocols for bundle segmentation is greater than all other sources of variability in the virtual dissection process, including variability within protocols and variability across subjects. In order to foster the use of tractography bundle dissection in routine clinical settings, and as a fundamental analytical tool, future endeavors must aim to resolve and reduce this heterogeneity. Although external validation is needed to verify the anatomical accuracy of bundle dissections, reducing heterogeneity is a step towards reproducible research and may be achieved through the use of standard nomenclature and definitions of white matter bundles and well-chosen constraints and decisions in the dissection process.
(Copyright © 2021. Published by Elsevier Inc.)
Databáze: MEDLINE
Externí odkaz: