Cholinergic modulation of dentate gyrus processing through dynamic reconfiguration of inhibitory circuits.

Autor:	Ogando MB; Instituto de Investigación en Biomedicina de Buenos Aires (IBioBA) - CONICET - Partner Institute of the Max Planck Society Godoy Cruz 2390, C1425FQD Buenos Aires, Argentina. Electronic address: moraogando@berkeley.edu., Pedroncini O; Instituto de Investigación en Biomedicina de Buenos Aires (IBioBA) - CONICET - Partner Institute of the Max Planck Society Godoy Cruz 2390, C1425FQD Buenos Aires, Argentina., Federman N; Instituto de Investigación en Biomedicina de Buenos Aires (IBioBA) - CONICET - Partner Institute of the Max Planck Society Godoy Cruz 2390, C1425FQD Buenos Aires, Argentina., Romano SA; Instituto de Investigación en Biomedicina de Buenos Aires (IBioBA) - CONICET - Partner Institute of the Max Planck Society Godoy Cruz 2390, C1425FQD Buenos Aires, Argentina., Brum LA; Fundación Instituto Leloir-Instituto de Investigaciones Bioquímicas de Buenos Aires-Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET), Av. Patricias Argentinas 435, Buenos Aires C1405BWE, Argentina., Lanuza GM; Fundación Instituto Leloir-Instituto de Investigaciones Bioquímicas de Buenos Aires-Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET), Av. Patricias Argentinas 435, Buenos Aires C1405BWE, Argentina., Refojo D; Instituto de Investigación en Biomedicina de Buenos Aires (IBioBA) - CONICET - Partner Institute of the Max Planck Society Godoy Cruz 2390, C1425FQD Buenos Aires, Argentina., Marin-Burgin A; Instituto de Investigación en Biomedicina de Buenos Aires (IBioBA) - CONICET - Partner Institute of the Max Planck Society Godoy Cruz 2390, C1425FQD Buenos Aires, Argentina. Electronic address: aburgin@ibioba-mpsp-conicet.gov.ar.
Jazyk:	angličtina
Zdroj:	Cell reports [Cell Rep] 2021 Aug 24; Vol. 36 (8), pp. 109572.
DOI:	10.1016/j.celrep.2021.109572
Abstrakt:	The dentate gyrus (DG) of the hippocampus plays a key role in memory formation, and it is known to be modulated by septal projections. By performing electrophysiology and optogenetics, we evaluated the role of cholinergic modulation in the processing of afferent inputs in the DG. We show that mature granule cells (GCs), but not adult-born immature neurons, have increased responses to afferent perforant path stimuli upon cholinergic modulation. This is due to a highly precise reconfiguration of inhibitory circuits, differentially affecting Parvalbumin and Somatostatin interneurons, resulting in a nicotinic-dependent perisomatic disinhibition of GCs. This circuit reorganization provides a mechanism by which mature GCs could escape the strong inhibition they receive, creating a window of opportunity for plasticity. Indeed, coincident activation of perforant path inputs with optogenetic release of acetylcholine produces a long-term potentiated response in GCs, essential for memory formation. Competing Interests: Declaration of interests The authors declare no competing interests. (Copyright © 2021 The Authors. Published by Elsevier Inc. All rights reserved.)
Databáze:	MEDLINE
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