| Autor: |
Khudyakov JI; Biological Sciences Department, University of the Pacific, Stockton, California., Treat MD; School of Life Sciences, University of Nevada, Las Vegas, Nevada., Shanafelt MC; Biological Sciences Department, University of the Pacific, Stockton, California., Deyarmin JS; Biological Sciences Department, University of the Pacific, Stockton, California., Neely BA; National Institute of Standards and Technology, Charleston, South Carolina., van Breukelen F; School of Life Sciences, University of Nevada, Las Vegas, Nevada. |
| Jazyk: |
angličtina |
| Zdroj: |
American journal of physiology. Regulatory, integrative and comparative physiology [Am J Physiol Regul Integr Comp Physiol] 2021 Oct 01; Vol. 321 (4), pp. R614-R624. Date of Electronic Publication: 2021 Aug 25. |
| DOI: |
10.1152/ajpregu.00150.2021 |
| Abstrakt: |
Many mammals use adaptive heterothermy (e.g., torpor, hibernation) to reduce metabolic demands of maintaining high body temperature ( T b ). Torpor is typically characterized by coordinated declines in T b and metabolic rate (MR) followed by active rewarming. Most hibernators experience periods of euthermy between bouts of torpor during which homeostatic processes are restored. In contrast, the common tenrec, a basoendothermic Afrotherian mammal, hibernates without interbout arousals and displays extreme flexibility in T b and MR. We investigated the molecular basis of this plasticity in tenrecs by profiling the liver proteome of animals that were active or torpid with high and more stable T b (∼32°C) or lower T b (∼14°C). We identified 768 tenrec liver proteins, of which 50.9% were differentially abundant between torpid and active animals. Protein abundance was significantly more variable in active cold and torpid compared with active warm animals, suggesting poor control of proteostasis. Our data suggest that torpor in tenrecs may lead to mismatches in protein pools due to poor coordination of anabolic and catabolic processes. We propose that the evolution of endothermy leading to a more realized homeothermy of boreoeutherians likely led to greater coordination of homeostatic processes and reduced mismatches in thermal sensitivities of metabolic pathways. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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