MRI/PET Imaging in elevated PSA and localized prostate cancer: a narrative review.

Autor:	Regmi SK; Department of Urology, University of Minnesota, Minneapolis, MN, USA., Sathianathen N; Department of Urology, University of Melbourne, Melbourne, Australia., Stout TE; Department of Urology, University of Minnesota, Minneapolis, MN, USA., Konety BR; Rush Medical College, Chicago, IL, USA.
Jazyk:	angličtina
Zdroj:	Translational andrology and urology [Transl Androl Urol] 2021 Jul; Vol. 10 (7), pp. 3117-3129.
DOI:	10.21037/tau-21-374
Abstrakt:	Objective: To review the recent milestones in MRI and PET based imaging and evaluate their evolving role in the setting of elevated PSA as well as localized prostate cancer. Background: The importance of multiparametric MRI (mpMRI) and PET based imaging for the diagnosis and staging of prostate cancer cannot be understated. Accurate staging has become another significant milestone with the use of PET scans, particularly with prostate specific radiotracers like 68-Gallium Prostate Specific Membrane Antigen (68Ga-PSMA). Integrated PET/MRI systems are commercially available and can be modulated to evaluate the unique needs of localized as well as recurrent prostate cancer. Methods: A literature search was performed using PubMed and Google Scholar using the MeSH compliant and other keywords that included prostate cancer, PSA, mpMRI, PET CT, PET/MRI. Conclusions: mpMRI has now established itself as the gold-standard of local prostate imaging and has been incorporated into international guidelines as part of the diagnostic work-up of prostate cancer. PSMA PET/CT has shown superiority over conventional imaging even in staging of localized prostate cancer based on recent randomized control data. Imaging parameters from PET/MRI have been shown to be associated with malignancy, Gleason score and tumour volume. As mpMRI and PSMA PET/CT become more ubiquitous and established; we can anticipate more high-quality data, cost optimization and increasing availability of PET/MRI to be ready for primetime in localized prostate cancer. Competing Interests: Conflicts of Interest: All authors have completed the ICMJE uniform disclosure form (available at https://dx.doi.org/10.21037/tau-21-374). The series “Current and Future Topics on Prostate Cancer” was commissioned by the editorial office without any funding or sponsorship. BRK serves as an unpaid editorial board member of Translational Andrology and Urology and served as the unpaid Guest Editor of the series. The authors have no other conflicts of interest to declare. (2021 Translational Andrology and Urology. All rights reserved.)
Databáze:	MEDLINE
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