Malic enzyme 2 promotes the progression of hepatocellular carcinoma via increasing triglyceride production.

Autor: Zhang S; Department of Interventional Radiology, The Affiliated Cancer Hospital of Guizhou Medical University, Guiyang, China.; Department of Interventional Radiology, The Affiliated Hospital of Guizhou Medical University, Guiyang, China., Cheng ZM; Department of Interventional Radiology, The Affiliated Hospital of Guizhou Medical University, Guiyang, China., Yu JL; Department of Interventional Radiology, The Affiliated Cancer Hospital of Guizhou Medical University, Guiyang, China., Lu K; Department of Interventional Radiology, The Affiliated Hospital of Guizhou Medical University, Guiyang, China., Xu SJ; Department of Interventional Radiology, The Affiliated Cancer Hospital of Guizhou Medical University, Guiyang, China., Lu Y; Guizhou Provincial Key Laboratory of Pharmaceutics, Guizhou Medical University, Guiyang, China., Liu T; Guizhou Provincial Key Laboratory of Pharmaceutics, Guizhou Medical University, Guiyang, China., Xia BJ; School of Basic Medical Sciences, Guizhou Medical University, Guiyang, China., Huang Z; Department of Radiology, the Affiliated Hospital of Guizhou Medical University, Guiyang, China., Zhao XY; Department of Interventional Radiology, The Affiliated Cancer Hospital of Guizhou Medical University, Guiyang, China., He W; Department of Interventional Radiology, The Affiliated Cancer Hospital of Guizhou Medical University, Guiyang, China., Li JX; Department of Interventional Radiology, The Affiliated Cancer Hospital of Guizhou Medical University, Guiyang, China., Cao W; Department of Interventional Radiology, The Affiliated Cancer Hospital of Guizhou Medical University, Guiyang, China., Huang Y; Department of Interventional Radiology, The Affiliated Cancer Hospital of Guizhou Medical University, Guiyang, China., Wang L; Department of Interventional Radiology, The Affiliated Cancer Hospital of Guizhou Medical University, Guiyang, China., Zeng Z; Guizhou Provincial Key Laboratory of Pharmaceutics, Guizhou Medical University, Guiyang, China., Zou X; Department of Radiology, the Affiliated Hospital of Guizhou Medical University, Guiyang, China., Liu R; Department of Interventional Radiology, First Affiliated Hospital of Guizhou, University of Traditional Chinese Medicine, Guiyang, China., Zhang YS; Department of Interventional Radiology, First Affiliated Hospital of Guizhou, University of Traditional Chinese Medicine, Guiyang, China., Wu XP; Department of Interventional Radiology, The Affiliated Hospital of Guizhou Medical University, Guiyang, China., Jiang TP; Department of Interventional Radiology, The Affiliated Hospital of Guizhou Medical University, Guiyang, China., Zhou S; Department of Interventional Radiology, The Affiliated Cancer Hospital of Guizhou Medical University, Guiyang, China.; Department of Interventional Radiology, The Affiliated Hospital of Guizhou Medical University, Guiyang, China.
Jazyk: angličtina
Zdroj: Cancer medicine [Cancer Med] 2021 Oct; Vol. 10 (19), pp. 6795-6806. Date of Electronic Publication: 2021 Aug 24.
DOI: 10.1002/cam4.4209
Abstrakt: The incidence and mortality of hepatocellular carcinoma (HCC) are gradually increasing during the past years. Recently, some studies have reported that malic enzyme (ME) plays an important role in cancer development, while the involvement of ME2 in HCC remains still undetermined. Here, we demonstrated that ME2 played an oncogenic role in HCC. ME2 was overexpressed in HCC tissues. TCGA database showed that the ME2 transcript level was inversely associated with the survival of HCC patients. Loss-of-function and gain-of-function assays showed that ME2 promoted HCC cell growth and migration. Furthermore, the xenografted tumorigenesis of MHCC97H cells was retarded by ME2 knockdown. ME2 silencing also suppressed the cell cycle process and induced apoptosis. Mechanistically, ME2 potentiated triglyceride synthesis, inhibition of which suppressed the proliferation and migration. We propose that ME2 promotes HCC progression by increasing triglyceride production.
(© 2021 The Authors. Cancer Medicine published by John Wiley & Sons Ltd.)
Databáze: MEDLINE
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