Diagnostic accuracy of optical coherence tomography for surgical margin assessment of feline injection-site sarcoma.

Autor: Coleman MJ; Department of Veterinary Clinical Sciences, College of Veterinary Medicine, The Ohio State University, Columbus, Ohio, USA., Selmic LE; Department of Veterinary Clinical Sciences, College of Veterinary Medicine, The Ohio State University, Columbus, Ohio, USA., Samuelson JP; Department of Veterinary Clinical Medicine, College of Veterinary Medicine, University of Illinois at Urbana-Champaign, Urbana, Illinois, USA., Jennings R; Department of Veterinary Biosciences, College of Veterinary Medicine, The Ohio State University, Columbus, Ohio, USA., Huang PC; Beckman Institute for Advanced Science and Technology, University of Illinois at Urbana-Champaign, Urbana, Illinois, USA.; Department of Bioengineering, University of Illinois at Urbana-Champaign, Urbana, Illinois, USA., McLaughlin EM; Center for Biostatistics, The Ohio State University, Columbus, Ohio, USA., Wavreille VA; Department of Veterinary Clinical Sciences, College of Veterinary Medicine, The Ohio State University, Columbus, Ohio, USA., Dornbusch JA; Department of Veterinary Clinical Sciences, College of Veterinary Medicine, The Ohio State University, Columbus, Ohio, USA., Lapsley J; Department of Veterinary Clinical Sciences, College of Veterinary Medicine, The Ohio State University, Columbus, Ohio, USA., Howard J; Department of Veterinary Clinical Sciences, College of Veterinary Medicine, The Ohio State University, Columbus, Ohio, USA., Cheng E; Department of Veterinary Clinical Sciences, College of Veterinary Medicine, The Ohio State University, Columbus, Ohio, USA., Kalamaras A; Department of Veterinary Clinical Sciences, College of Veterinary Medicine, The Ohio State University, Columbus, Ohio, USA., Hearon K; Department of Surgery, Metropolitan Veterinary Specialists, Philadelphia, Pennsylvannia, USA., Cray M; Department of Surgery, Angell Animal Medical Center, Boston, Massachusetts, USA., Grimes J; Department of Small Animal Medicine and Surgery, College of Veterinary Medicine, University of Georgia, Athens, Georgia, USA., Wustefeld-Janssens B; Department of Veterinary Clinical Sciences, College of Veterinary Medicine, Texas A & M University, College Station, Texas, USA., Kennedy K; Department of Surgery, Animal Medical Center, New York City, New York, USA., Skinner O; Department of Veterinary Clinical Sciences, College of Veterinary Medicine, University of Missouri, Columbia, Missouri, USA., Amsellem P; Department of Veterinary Medicine and Surgery, College of Veterinary Medicine, University of Minnesota, Twin Cities, Minnesota, USA., Boppart SA; Beckman Institute for Advanced Science and Technology, University of Illinois at Urbana-Champaign, Urbana, Illinois, USA.; Department of Bioengineering, University of Illinois at Urbana-Champaign, Urbana, Illinois, USA.; Department of Electrical and Computer Engineering, University of Illinois at Urbana-Champaign, Urbana, Illinois, USA.; Carle Illinois College of Medicine, University of Illinois at Urbana-Champaign, Urbana, Illinois, USA.
Jazyk: angličtina
Zdroj: Veterinary and comparative oncology [Vet Comp Oncol] 2021 Dec; Vol. 19 (4), pp. 632-640. Date of Electronic Publication: 2021 Sep 14.
DOI: 10.1111/vco.12766
Abstrakt: The invasive, locally aggressive nature of feline injection-site sarcomas (FISSs) poses a unique challenge for surgeons to obtain complete margins with surgical excision. Optical coherence tomography (OCT), an imaging technology that uses light waves to generate real-time views of tissue architecture, provides an emerging solution to this dilemma by allowing fast, high-resolution scanning of surgical margins. The purpose of this study was to use OCT to assess surgical margins of FISS and to evaluate the diagnostic accuracy of OCT for detecting residual cancer using six evaluators of varying experience. Five FISSs were imaged with OCT to create a training set of OCT images that were compared with histopathology. Next, 25 FISSs were imaged with OCT prior to histopathology. Six evaluators of varying experience participated in a training session on OCT imaging after which each of the evaluators was given a dataset that included OCT images and videos to score on a scale from cancerous to non-cancerous. Diagnostic accuracy statistics were calculated. The overall sensitivity and specificity for classification of OCT images by evaluators were 78.9% and 77.6%, respectively. Correct classification rate of OCT images was associated with experience, while individual sensitivities and specificities had more variation between experience groups. This study demonstrates the ability of evaluators to correctly classify OCT images with overall low levels of experience and training and also illustrates areas where increased training can improve accuracy of evaluators in interpretation of OCT surgical margin images.
(© 2021 John Wiley & Sons Ltd.)
Databáze: MEDLINE
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