Identification of neural progenitor cells and their progeny reveals long distance migration in the developing octopus brain.
| Autor: | Deryckere A; Laboratory of Developmental Neurobiology, Department of Biology, KU Leuven, Leuven, Belgium., Styfhals R; Laboratory of Developmental Neurobiology, Department of Biology, KU Leuven, Leuven, Belgium.; Department of Biology and Evolution of Marine Organisms, Stazione Zoologica Anton Dohrn, Naples, Italy., Elagoz AM; Laboratory of Developmental Neurobiology, Department of Biology, KU Leuven, Leuven, Belgium., Maes GE; Center for Human Genetics, Genomics Core, UZ-KU Leuven, Leuven, Belgium.; Centre for Sustainable Tropical Fisheries and Aquaculture, College of Science and Engineering, James Cook University, Townsville, Australia.; Laboratory of Biodiversity and Evolutionary Genomics, Department of Biology, KU Leuven, Leuven, Belgium., Seuntjens E; Laboratory of Developmental Neurobiology, Department of Biology, KU Leuven, Leuven, Belgium. |
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| Jazyk: | angličtina |
| Zdroj: | ELife [Elife] 2021 Aug 24; Vol. 10. Date of Electronic Publication: 2021 Aug 24. |
| DOI: | 10.7554/eLife.69161 |
| Abstrakt: | Cephalopods have evolved nervous systems that parallel the complexity of mammalian brains in terms of neuronal numbers and richness in behavioral output. How the cephalopod brain develops has only been described at the morphological level, and it remains unclear where the progenitor cells are located and what molecular factors drive neurogenesis. Using histological techniques, we located dividing cells, neural progenitors and postmitotic neurons in Octopus vulgaris embryos. Our results indicate that an important pool of progenitors, expressing the conserved bHLH transcription factors achaete-scute or neurogenin , is located outside the central brain cords in the lateral lips adjacent to the eyes, suggesting that newly formed neurons migrate into the cords. Lineage-tracing experiments then showed that progenitors, depending on their location in the lateral lips, generate neurons for the different lobes, similar to the squid Doryteuthis pealeii . The finding that octopus newborn neurons migrate over long distances is reminiscent of vertebrate neurogenesis and suggests it might be a fundamental strategy for large brain development. Competing Interests: AD, RS, AE, GM, ES No competing interests declared (© 2021, Deryckere et al.) |
| Databáze: | MEDLINE |
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