Perianal Crohn's disease: clinical implications, prognosis and use of resources.

Autor:	Martínez Sánchez ER; Aparato Digestivo, Hospital Universitario Virgen del Rocío, España., Solá Fernández A; Aparato Digestivo, Hospital Universitario Virgen del Rocío., Pérez Palacios D; Aparato Digestivo, Hospital Universitario Virgen del Rocío., Núñez Ortiz A; Aparato Digestivo, Hospital Universitario Virgen del Rocío, España., de la Cruz Ramírez MD; Aparato Digestivo, Hospital Universitario Virgen del Rocío., Leo Carnerero E; Aparato Digestivo, Hospital Universitario Virgen del Rocío. ., Trigo Salado C; Aparato Digestivo, Hospital Universitario Virgen del Rocío., Herrera Justiniano JM; Aparato Digestivo, Hospital Universitario Virgen del Rocío.
Jazyk:	angličtina
Zdroj:	Revista espanola de enfermedades digestivas [Rev Esp Enferm Dig] 2022 May; Vol. 114 (5), pp. 254-258.
DOI:	10.17235/reed.2021.7918/2021
Abstrakt:	Objective: to investigate the prevalence of perianal disease, the associated phenotypical factors, its influence on prognosis and its impact on the use of health resources for patients with Crohn's disease. Methods: a unicentric retrospective observational study was performed with 430 patients with Crohn's disease tracked through a monographical consultation of intestinal inflammatory disease. Demographic and phenotypical data of Crohn's disease, pharmacological and surgical treatments, complementary tests carried out and hospital admissions were analyzed. A comparative study between those patients without perianal disease and those with perianal disease was performed, both in simple form and complex form. Results: the prevalence of perianal disease was 40.2 %, and fistulas and abscesses were the most frequent manifestations. These appearances were associated with an affected rectum and the existence of extra-intestinal manifestations. The patients with perianal disease most frequently required immuno-suppressant and biological treatment, but no further abdominal surgery. Amongst the patients with perianal disease, the need for biologics was more frequent for luminal disease (42.8 % vs 30.7 %). Furthermore, more explorations were needed, aimed at the study of perianal disease and recto-colonoscopies, although more magnetic resonance (MR)/computed tomography (CT) enterographies were not required. Conclusions: perianal disease has a high prevalence among patients with Crohn's disease, especially when the rectum is affected. It is associated with a worse prognosis and more frequently requires biological treatments due to perianal and luminal evolution, especially in cases of complex perianal disease. This condition calls for more hospital admissions and complementary tests.
Databáze:	MEDLINE
Externí odkaz:	Zobrazit plný text záznamu