Pain modulated by Bothrops snake venoms: Mechanisms of nociceptive signaling and therapeutic perspectives.

Autor: Cavalcante JDS; Graduate Program in Tropical Diseases, Botucatu Medical School (FMB), São Paulo State University, Botucatu, São Paulo, Brazil. Electronic address: joeliton.cavalcante@unesp.br., Nogueira Júnior FA; Department of Physiology and Pharmacology and Drug Research and Development Center Federal University of Ceará, Fortaleza, Ceará, Brazil., Bezerra Jorge RJ; Department of Physiology and Pharmacology and Drug Research and Development Center Federal University of Ceará, Fortaleza, Ceará, Brazil., Almeida C; Center of Mathematics, Computing Sciences and Cognition, Federal University of ABC, São Paulo, Brazil. Electronic address: cayo.almeida@ufabc.edu.br.
Jazyk: angličtina
Zdroj: Toxicon : official journal of the International Society on Toxinology [Toxicon] 2021 Oct 15; Vol. 201, pp. 105-114. Date of Electronic Publication: 2021 Aug 21.
DOI: 10.1016/j.toxicon.2021.08.016
Abstrakt: Snake venoms are substances mostly composed by proteins and peptides with high biological activity. Local and systemic effects culminate in clinical manifestations induced by these substances. Pain is the most uncomfortable condition, but it has not been well investigated. This review discusses Bothrops snakebite-induced nociception, highlighting molecules involved in the mediation of this process and perspectives in treatment of pain induced by Bothrops snake venoms (B. alternatus, B. asper, B. atrox, B. insularis, B. jararaca, B. pirajai, B. jararacussu, B. lanceolatus, B. leucurus, B. mattogrossensis, B. moojeni). We highlight, the understanding of the nociceptive signaling, especially in snakebite, enables more efficient treatment approaches. Finally, future perspectives for pain treatment concerning snakebite patients are discussed.
(Copyright © 2021 Elsevier Ltd. All rights reserved.)
Databáze: MEDLINE
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