Neuropeptidergic and Neuroendocrine Systems Underlying Eusociality and the Concomitant Social Regulation of Reproduction in Naked Mole-Rats: A Comparative Approach.
| Autor: | Coen CW; Reproductive Neurobiology, Division of Women's Health, Faculty of Life Sciences & Medicine, King's College London, London, UK. clive.coen@kcl.ac.uk., Bennett NC; Mammal Research Institute, Department of Zoology and Entomology, University of Pretoria, Pretoria, South Africa., Holmes MM; Department of Psychology, University of Toronto Mississauga, Mississauga, ON, Canada.; Department of Ecology & Evolutionary Biology, University of Toronto, Toronto, Canada.; Department of Cell & Systems Biology, University of Toronto, Toronto, Canada., Faulkes CG; School of Biological and Chemical Sciences, Queen Mary University of London, London, UK. |
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| Jazyk: | angličtina |
| Zdroj: | Advances in experimental medicine and biology [Adv Exp Med Biol] 2021; Vol. 1319, pp. 59-103. |
| DOI: | 10.1007/978-3-030-65943-1_3 |
| Abstrakt: | The African mole-rat family (Bathyergidae) includes the first mammalian species identified as eusocial: naked mole-rats. Comparative studies of eusocial and solitary mole-rat species have identified differences in neuropeptidergic systems that may underlie the phenomenon of eusociality. These differences are found in the oxytocin, vasopressin and corticotrophin-releasing factor (CRF) systems within the nucleus accumbens, amygdala, bed nucleus of the stria terminalis and lateral septal nucleus. As a corollary of their eusociality, most naked mole-rats remain pre-pubertal throughout life because of the presence of the colony's only reproductive female, the queen. To elucidate the neuroendocrine mechanisms that mediate this social regulation of reproduction, research on the hypothalamo-pituitary-gonadal axis in naked mole-rats has identified differences between the many individuals that are reproductively suppressed and the few that are reproductively mature: the queen and her male consorts. These differences involve gonadal steroids, gonadotrophin-releasing hormone-1 (GnRH-1), kisspeptin, gonadotrophin-inhibitory hormone/RFamide-related peptide-3 (GnIH/RFRP-3) and prolactin. The comparative findings in eusocial and solitary mole-rat species are assessed with reference to a broad range of studies on other mammals. (© 2021. Springer Nature Switzerland AG.) |
| Databáze: | MEDLINE |
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