Withanolides from Physalis angulata L.

Autor: Okmanov RY; S.Yunusov Institute of the Chemistry of Plant Substances Academy of Sciences, of Uzbekistan 100170, Mirzo Ulugbek Str., 77, Tashkent, Uzbekistan., Makhmudova MM; S.Yunusov Institute of the Chemistry of Plant Substances Academy of Sciences, of Uzbekistan 100170, Mirzo Ulugbek Str., 77, Tashkent, Uzbekistan., Bobaev ID; S.Yunusov Institute of the Chemistry of Plant Substances Academy of Sciences, of Uzbekistan 100170, Mirzo Ulugbek Str., 77, Tashkent, Uzbekistan.; Tashkent Chemical-Technological Institute, of Uzbekistan 100011, A. Navoiy Str., 32, Tashkent, Uzbekistan., Tashkhodjaev B; S.Yunusov Institute of the Chemistry of Plant Substances Academy of Sciences, of Uzbekistan 100170, Mirzo Ulugbek Str., 77, Tashkent, Uzbekistan.
Jazyk: angličtina
Zdroj: Acta crystallographica. Section E, Crystallographic communications [Acta Crystallogr E Crystallogr Commun] 2021 Jul 16; Vol. 77 (Pt 8), pp. 804-808. Date of Electronic Publication: 2021 Jul 16 (Print Publication: 2021).
DOI: 10.1107/S205698902100709X
Abstrakt: The compounds (17 S ,20 R ,22 R ,24 R ,25 S )-5β,6β:20,24-diep-oxy-4β,25-dihy-droxy-1-oxowith-2-en-26,22-olide and (20 R ,22 R )-5α,14α,20-Trihy-droxy-1-oxo-6α,7α-ep-oxy-witha-2-enolide were isolated from a chloro-form extract of the aerial parts of Physalis angulata L. (Solanaceae). Two products were isolated from the chromatographic separation extract. Compound I corresponds to physangulide B chloro-form monosolvate, C 28 H 38 O 7 ·CHCl 3 , while compound II is 14α-hy-droxy-ixocarpanolide, C 28 H 40 O 7 . In the two mol-ecular structures, the conformation of the steroid part (rings A , B , C , D ) does not differ. In both crystals, mol-ecules are linked by inter-molecular O-H⋯O hydrogen bonds along the c- axis direction and form a two-dimensional network parallel to the ac plane. The absolute configuration was determined from X-ray diffraction data.
(© Okmanov et al. 2021.)
Databáze: MEDLINE