Normal Values of Left Atrial Size and Function and the Impact of Age: Results of the World Alliance Societies of Echocardiography Study.

Autor:	Singh A; University of Chicago, Chicago, Illinois., Carvalho Singulane C; University of Chicago, Chicago, Illinois; São José do Rio Preto Medical School, São José do Rio Preto, Brazil., Miyoshi T; MedStar Health Research Institute, Washington, District of Columbia., Prado AD; Centro Privado de Cardiologia, Tucumán, Argentina., Addetia K; University of Chicago, Chicago, Illinois., Bellino M; University of Salerno, Salerno, Italy., Daimon M; University of Tokyo, Tokyo, Japan., Gutierrez Fajardo P; Hospital Bernardette, Guadalajara, Mexico., Kasliwal RR; Medanta Medicity, Gurgaon, India., Kirkpatrick JN; University of Washington, Seattle, Washington., Monaghan MJ; King's College Hospital, London, United Kingdom., Muraru D; University of Milano-Bicocca and Istituto Auxologico Italiano, IRCCS, Milan, Italy., Ogunyankin KO; First Cardiology Consultants Hospital Ikoyi, Lagos, Nigeria., Park SW; Samsung Medical Center/Sungkyunkwan University School of Medicine, Seoul, Korea., Ronderos RE; Instituto Cardiovascular de Buenos Aires, Buenos Aires, Argentina., Sadeghpour A; Rajaie Cardiovascular Medical Center, Iran University of Medical Sciences, Tehran, Iran., Scalia GM; GenesisCare, Brisbane, Australia., Takeuchi M; University of Occupational and Environmental Health, Kitakyushu, Japan., Tsang W; Toronto General Hospital, University Health Network, University of Toronto, Toronto, Ontario, Canada., Tucay ES; Philippine Heart Center, Quezon City, Philippines., Tude Rodrigues AC; Hospital Israelita Albert Einstein, São Paulo, Brazil., Vivekanandan A; Jeyalakshmi Heart Center, Madurai, India., Zhang Y; Qilu Hospital of Shandong University, Jinan, China., Schreckenberg M; TomTec Imaging Systems, Unterschleissheim, Germany., Blankenhagen M; TomTec Imaging Systems, Unterschleissheim, Germany., Degel M; TomTec Imaging Systems, Unterschleissheim, Germany., Hitschrich N; TomTec Imaging Systems, Unterschleissheim, Germany., Mor-Avi V; University of Chicago, Chicago, Illinois., Asch FM; MedStar Health Research Institute, Washington, District of Columbia., Lang RM; University of Chicago, Chicago, Illinois. Electronic address: rlang@medicine.bsd.uchicago.edu.
Jazyk:	angličtina
Zdroj:	Journal of the American Society of Echocardiography : official publication of the American Society of Echocardiography [J Am Soc Echocardiogr] 2022 Feb; Vol. 35 (2), pp. 154-164.e3. Date of Electronic Publication: 2021 Aug 18.
DOI:	10.1016/j.echo.2021.08.008
Abstrakt:	Background: Left atrial (LA) evaluation includes volumetric and functional parameters with an abundance of diagnostic and prognostic implications. Solid normal reference ranges are compulsory for accurate interpretation in individual patients, but previous studies have yielded mixed conclusions regarding the effects of age, sex, and/or race. The present report from the World Alliance Societies of Echocardiography study focuses on two-dimensional (2D) and three-dimensional (3D) measures of LA structure and function, with subgroup analysis by age, sex, and race. Methods: Transthoracic 2D and 3D echocardiographic images were obtained in 1,765 healthy individuals (901 men, 864 women) evenly distributed among age subgroups: 18 to 40 years (n = 745), 41 to 65 years (n = 618), and >65 years (n = 402); the racial distribution was 38.4% white, 39.9% Asian, and 9.7% black. Images were analyzed using dedicated LA analysis software to measure LA volumes and phasic function from 3D volume and 2D strain curves. Results: Three-dimensional maximum and minimum LA volumes adjusted for body surface area were nearly identical for men and women, but women demonstrated higher 3D total and passive emptying fractions (EFs). Two-dimensional reservoir strain was similar for both sexes. Age was associated with an incremental rise in LA volumes alongside characteristic shifts in functional indices. Total 2D EF and reservoir and conduit strain varied inversely with age, counteracted by higher booster strain, with a greater magnitude of effect in women. Active 3D EF was significantly higher, while total and passive EFs decreased with age. Interracial differences were noted in LA volumes, without substantial differences in functional indices. Conclusion: Although similar normal values for LA volumes and strain can be applied to both sexes, meaningful differences in LA size occur with aging. Indices of function also shift with age, with a compensatory rise in booster function, which may serve to counteract observed lower total and passive EFs. Defining age-associated normal values may help differentiate age-associated "healthy" LA aging from pathologic processes. (Copyright © 2021 American Society of Echocardiography. Published by Elsevier Inc. All rights reserved.)
Databáze:	MEDLINE
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