[A pilot study of cytokine profile in cerebrospinal fluid of children with acute lymphocytic leukemia and neurotoxic side effects of chemotherapy].

Autor:	Bazarnyi VV; Ural State Medical University, Yekaterinburg, Russia., Kovtun OP; Ural State Medical University, Yekaterinburg, Russia., Koryakina OV; Ural State Medical University, Yekaterinburg, Russia; Regional Children's Clinical Hospital, Yekaterinburg, Russia., Polushina LG; Ural State Medical University, Yekaterinburg, Russia., Maksimova AY; Ural State Medical University, Yekaterinburg, Russia.
Jazyk:	ruština
Zdroj:	Biomeditsinskaia khimiia [Biomed Khim] 2021 Jul; Vol. 67 (4), pp. 374-377.
DOI:	10.18097/PBMC20216704374
Abstrakt:	In some cases standard chemotherapy of acute lymphocytic leukemia (ALL) leads to neurotoxicity; its mechanisms, methods of prognosis, and prevention are being actively studied. The aim of this study was to assess the cytokine profile in cerebrospinal fluid (CSF) of children with ALL and neurotoxic side effects of chemotherapy. This prospective study included 24 children with ALL aged from 3 to 17 years. Patients were further subdivided into ALL patients with (main group) and without neurological complications (comparison group). The level of cytokines in CSF was measured by Xmap technology (Luminex) using Invitrogen test systems (eBioscience) and the Luminex 200 system. The comparative analysis of the cytokine profile in the group of children with chemotherapy-induced neurotoxic complications revealed elevated levels of chemokine CXCL12 (SDF-1α) and stem cell factor (SCF). Increased level of these cytokines in CSF was characterized by a relatively risk for development of toxic peripheral neuropathy.
Databáze:	MEDLINE
Externí odkaz:	Zobrazit plný text záznamu