Metabolic decisions in development and disease-a Keystone Symposia report.

Autor: Cable J; PhD Science Writer, New York, New York., Pourquié O; Department of Genetics, Harvard Medical School, Boston, Massachusetts.; Department of Pathology, Brigham and Women's Hospital, Boston, Massachusetts.; Harvard Stem Cell Institute, Boston, Massachusetts., Wellen KE; Department of Cancer Biology, University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania., Finley LWS; Cell Biology Program and Center for Epigenetics Research, Memorial Sloan Kettering Cancer Center, New York, New York., Aulehla A; Developmental Biology Unit, European Molecular Biology Laboratory, Heidelberg, Germany., Gould AP; The Francis Crick Institute, London, UK., Teleman A; German Cancer Research Center (DKFZ) and Heidelberg University, Heidelberg, Germany., Tu WB; Department of Biological Chemistry, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, California., Garrett WS; Harvard T. H. Chan School of Public Health and Dana-Farber Cancer, Boston, Massachusetts., Miguel-Aliaga I; MRC London Institute of Medical Sciences and Institute of Clinical Sciences, Faculty of Medicine, Imperial College London, London, UK., Perrimon N; Department of Genetics, Blavatnik Institute, Harvard Medical School and Howard Hughes Institute, Boston, Massachusetts., Hooper LV; Department of Immunology and Howard Hughes Medical Institute, University of Texas Southwestern Medical Center, Dallas, Texas., Walhout AJM; Program in Systems Biology and Program in Molecular Medicine, University of Massachusetts Medical School, Worcester, Massachusetts., Wei W; Department of Pathology, Stanford University School of Medicine, Stanford, California.; Department of Biology and Stanford ChEM-H, Stanford University, Stanford, California., Alexandrov T; Structural and Computational Biology Unit and Molecular Medicine Partnership Unit, European Molecular Biology Laboratory, Heidelberg, Germany.; Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California San Diego, La Jolla, California., Erez A; Department of Biological Regulation, Weizmann Institute of Science, Rehovot, Israel., Ralser M; Molecular Biology of Metabolism Laboratory, The Francis Crick Institute, London, UK.; Department of Biochemistry, Charité - Universitätsmedizin Berlin, Freie Universität Berlin and Humboldt-Universität zu Berlin, Berlin, Germany., Rabinowitz JD; Department of Chemistry and Lewis-Sigler Institute for Integrative Genomics, Princeton University, Princeton, New Jersey., Hemalatha A; Department of Genetics, Yale School of Medicine, New Haven, Connecticut., Gutiérrez-Pérez P; Research Institute of Molecular Pathology (IMP), Vienna BioCenter (VBC), Vienna, Austria., Chandel NS; Department of Medicine, Robert H. Lurie Cancer Center, Chicago, Illinois.; Department of Biochemistry and Molecular Genetics, Robert H. Lurie Cancer Center Metabolomics Core, Northwestern University Feinberg School of Medicine, Chicago, Illinois., Rutter J; Department of Biochemistry and Howard Hughes Medical Institute, University of Utah, Salt Lake City, Utah., Locasale JW; Department of Pharmacology and Cancer Biology, Duke University School of Medicine, Durham, North Carolina., Landoni JC; Research Program in Stem Cells and Metabolism, University of Helsinki, Helsinki, Finland., Christofk H; Departments of Biological Chemistry and Molecular & Medical Pharmacology, David Geffen School of Medicine at UCLA, Los Angeles, California.
Jazyk: angličtina
Zdroj: Annals of the New York Academy of Sciences [Ann N Y Acad Sci] 2021 Dec; Vol. 1506 (1), pp. 55-73. Date of Electronic Publication: 2021 Aug 19.
DOI: 10.1111/nyas.14678
Abstrakt: There is an increasing appreciation for the role of metabolism in cell signaling and cell decision making. Precise metabolic control is essential in development, as evident by the disorders caused by mutations in metabolic enzymes. The metabolic profile of cells is often cell-type specific, changing as cells differentiate or during tumorigenesis. Recent evidence has shown that changes in metabolism are not merely a consequence of changes in cell state but that metabolites can serve to promote and/or inhibit these changes. Metabolites can link metabolic pathways with cell signaling pathways via several mechanisms, for example, by serving as substrates for protein post-translational modifications, by affecting enzyme activity via allosteric mechanisms, or by altering epigenetic markers. Unraveling the complex interactions governing metabolism, gene expression, and protein activity that ultimately govern a cell's fate will require new tools and interactions across disciplines. On March 24 and 25, 2021, experts in cell metabolism, developmental biology, and human disease met virtually for the Keystone eSymposium, "Metabolic Decisions in Development and Disease." The discussions explored how metabolites impact cellular and developmental decisions in a diverse range of model systems used to investigate normal development, developmental disorders, dietary effects, and cancer-mediated changes in metabolism.
(© 2021 New York Academy of Sciences.)
Databáze: MEDLINE
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