Legionella feeleii : Ubiquitous Pathogen in the Environment and Causative Agent of Pneumonia.

Autor:	Vaccaro L; Departamento Ciencias Farmacéuticas y de la Salud, Facultad de Farmacia, Universidad San Pablo-CEU, CEU Universities, Madrid, Spain., Gomes TS; Departamento Ciencias Farmacéuticas y de la Salud, Facultad de Farmacia, Universidad San Pablo-CEU, CEU Universities, Madrid, Spain.; Coordenação de Aperfeiçoamento de Pessoal de Nivel Superior (CAPES) Foundation, Ministry of Education of Brazil, Brasília, Brazil., Izquierdo F; Departamento Ciencias Farmacéuticas y de la Salud, Facultad de Farmacia, Universidad San Pablo-CEU, CEU Universities, Madrid, Spain., Magnet A; Departamento Ciencias Farmacéuticas y de la Salud, Facultad de Farmacia, Universidad San Pablo-CEU, CEU Universities, Madrid, Spain., Llorens Berzosa S; Departamento Ciencias Farmacéuticas y de la Salud, Facultad de Farmacia, Universidad San Pablo-CEU, CEU Universities, Madrid, Spain., Ollero D; Departamento Ciencias Farmacéuticas y de la Salud, Facultad de Farmacia, Universidad San Pablo-CEU, CEU Universities, Madrid, Spain., Salso S; Hospital Universitario HM Monteprincipe y Sanchinarro, Madrid, Spain., Alhambra A; Hospital Universitario HM Monteprincipe y Sanchinarro, Madrid, Spain., Gómez C; Hospital Universitario HM Monteprincipe y Sanchinarro, Madrid, Spain., López Cano M; Hospital Universitario HM Monteprincipe y Sanchinarro, Madrid, Spain., Pelaz C; Unidad de Legionella, Laboratorio de Referencia e Investigación en Infecciones Bacterianas Transmitidas por Agua y Alimentos, Centro Nacional de Microbiología (CNM), Instituto de Salud Carlos III (ISCIII), Madrid, Spain., Bellido Samaniego B; Unidad de Legionella, Laboratorio de Referencia e Investigación en Infecciones Bacterianas Transmitidas por Agua y Alimentos, Centro Nacional de Microbiología (CNM), Instituto de Salud Carlos III (ISCIII), Madrid, Spain., Del Aguila C; Departamento Ciencias Farmacéuticas y de la Salud, Facultad de Farmacia, Universidad San Pablo-CEU, CEU Universities, Madrid, Spain., Fenoy S; Departamento Ciencias Farmacéuticas y de la Salud, Facultad de Farmacia, Universidad San Pablo-CEU, CEU Universities, Madrid, Spain., Hurtado-Marcos C; Departamento Ciencias Farmacéuticas y de la Salud, Facultad de Farmacia, Universidad San Pablo-CEU, CEU Universities, Madrid, Spain.
Jazyk:	angličtina
Zdroj:	Frontiers in microbiology [Front Microbiol] 2021 Aug 03; Vol. 12, pp. 707187. Date of Electronic Publication: 2021 Aug 03 (Print Publication: 2021).
DOI:	10.3389/fmicb.2021.707187
Abstrakt:	L. feeleii is one of the most frequent Legionella species isolated from natural pools of the central region of Spain. This study aimed to evaluate its ecology and to identify this Legionella species as a respiratory pathogen. A PCR assay for detecting the L. feeleii mip gene was developed to identify it in clinical and environmental samples. Culture and PCR were performed in environmental samples from four drinking water treatment plants (DWTPs). Free L. feeleii was only detected in raw water samples (3.4%), while L. feeleii as an Acanthamoeba endosymbiont was found in 30.7% of raw water, 11.5% of decanter biofilm, and 32% of finished water samples. Therefore, Acanthamoeba spp. plays an essential role in the multiplication, persistence, and spread of Legionella species in the environment. The first case of Legionnaires' disease caused by L. feeleii in Spain is described in this study. The case was diagnosed in an older woman through PCR and sequencing from urine and sputum samples. A respiratory infection could be linked with health care procedures, and the patient presented several risk factors (age, insulin-dependent diabetes, and heart disease). The detection of non- L . pneumophila , such as L. feeleii , is a factor that must be considered when establishing or reviewing measures for the control and prevention of legionellosis. Competing Interests: The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. (Copyright © 2021 Vaccaro, Gomes, Izquierdo, Magnet, Llorens Berzosa, Ollero, Salso, Alhambra, Gómez, López Cano, Pelaz, Bellido Samaniego, del Aguila, Fenoy and Hurtado-Marcos.)
Databáze:	MEDLINE
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