Clostridium difficile Infection Leading to Intestinal Pneumatosis in a Patient with a Recent Diagnosis of Pancreatic Cancer Local Recurrence: A Case Report and Literature Review.

Autor: Uchiyama AAT; Oncology, Hospital Alemão Oswaldo Cruz, São Paulo, Brazil., Lopes MSM; Oncology, Hospital Alemão Oswaldo Cruz, São Paulo, Brazil., Vana MNM; Gastroenterology, Hospital Alemão Oswaldo Cruz, São Paulo, Brazil., Peixoto RD; Oncology, Centro Paulista de Oncologia - Grupo Oncoclínicas, São Paulo, Brazil.
Jazyk: angličtina
Zdroj: Case reports in oncology [Case Rep Oncol] 2021 Jul 15; Vol. 14 (2), pp. 1111-1117. Date of Electronic Publication: 2021 Jul 15 (Print Publication: 2021).
DOI: 10.1159/000513003
Abstrakt: Clostridium difficile infection (CDI) causing pneumatosis intestinalis (PI) is a rare event, described mostly in immunocompromised patients. We present the case of a 65-year-old female diagnosed with adenocarcinoma of the pancreas who underwent a duodenopancreatectomy with lymphadenectomy and adjuvant gemcitabine and capecitabine. Four months after the end of chemotherapy, she experienced abdominal pain and intermittent diarrhea which became aggravated within 6 months. CT scans revealed diffuse intestinal pneumatosis and recurrence of ductal adenocarcinoma. We hypothesize that local pancreatic cancer recurrence may lead to gastrointestinal dysmotility with consequent increased risk for CDI. The patient had almost complete resolution of PI during the CDI treatment, thus we believe that the CDI was directly responsible for PI in this case.
Competing Interests: The authors declare no conflicts of interest.
(Copyright © 2021 by S. Karger AG, Basel.)
Databáze: MEDLINE
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