Detrimental effect of diabetes and hypertension on the severity and mortality of COVID-19 infection: A multi-center case-control study from India.

Autor: Jayaswal SK; Department of Biochemical Engineering and Biotechnology, Indian Institute of Technology, Hauz Khas, New Delhi, 110016, India. Electronic address: drsnehakj@gmail.com., Singh S; Department of Anesthesiology and Critical Care, Armed Forces Medical College, Pune, 411040, Maharashtra, India. Electronic address: drsinghafmc@gmail.com., Malik PS; Department of Medical Oncology, All India Institute of Medical Sciences, Ansari Nagar, New Delhi, 10029, India. Electronic address: drprabhatsm@gmail.com., Venigalla SK; Department of Anesthesiology and Critical Care, Armed Forces Medical College, Pune, 411040, Maharashtra, India. Electronic address: srikrishna9@gmail.com., Gupta P; Department of Biological Sciences, Indian Institute of Science Education and Research, Bhopal, Bhauri, Madhya Pradesh, 462066, India. Electronic address: pgupta3005@gmail.com., Samaga SN; Department of Biochemical Engineering and Biotechnology, Indian Institute of Technology, Hauz Khas, New Delhi, 110016, India. Electronic address: samagashreyas@gmail.com., Hota RN; Department of Anesthesiology and Critical Care, Armed Forces Medical College, Pune, 411040, Maharashtra, India. Electronic address: rabi072027@gmail.com., Bhatia SS; DGAFMS Office, Ministry of Defence, New Delhi, 110010, India. Electronic address: Bhatia_sssss@yahoo.co.in., Gupta I; Department of Biochemical Engineering and Biotechnology, Indian Institute of Technology, Hauz Khas, New Delhi, 110016, India. Electronic address: ishaan@iitd.ac.in.
Jazyk: angličtina
Zdroj: Diabetes & metabolic syndrome [Diabetes Metab Syndr] 2021 Sep-Oct; Vol. 15 (5), pp. 102248. Date of Electronic Publication: 2021 Aug 15.
DOI: 10.1016/j.dsx.2021.102248
Abstrakt: Aims: This study aims to find a quantitative association between the presence of co-existing diabetes mellitus (DM) and/or hypertension (HTN) with COVID-19 infection severity and mortality.
Methods: A total of 813 patients with a positive COVID-19 were included. A case-control design was used to dissect the association between DM and HTN with COVID-19 severity and mortality.
Results: According to MOHFW guidelines, 535 (65.7%) patients had mild, 160 (19.7%) patients had moderate, and 118 (14.5%) patients had severe disease outcomes including mortality in 52 patients. Age, Neutrophil%, and Diabetes status were significantly associated with severe COVID-19 infection. After adjusting for age, patients with diabetes were 2.46 times more likely to have severe disease (Chi-squared = 18.89, p-value<0.0001) and 2.11 times more likely to have a fatal outcome (Chi-squared = 6.04, p-value = 0.014). However, we did not find evidence for Hypertension modifying the COVID-19 outcomes in Diabetic patients.
Conclusion: COVID-19 severity and mortality both were significantly associated with the status of DM and its risk may not be modified by the presence of HTN.
Competing Interests: Declaration of competing interest The authors have no conflict of interest.
(Copyright © 2021 Diabetes India. Published by Elsevier Ltd. All rights reserved.)
Databáze: MEDLINE
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