Auxin drives tomato spotted wilt virus (TSWV) resistance through epigenetic regulation of auxin response factor ARF8 expression in tomato.

Autor: Werghi S; Laboratory of Molecular Genetics, Immunology and Biotechnology, Faculty of Sciences of Tunis, University of Tunis El Manar, Tunis 2092, Tunisia., Herrero FA; Institute of Molecular and Cellular Biology of Plants (UPV-CSIC), Valencia 46022, Spain; Dept of Biotechnology, ETSIAMN, Universidad Politécnica de Valencia, 46002, Spain., Fakhfakh H; Laboratory of Molecular Genetics, Immunology and Biotechnology, Faculty of Sciences of Tunis, University of Tunis El Manar, Tunis 2092, Tunisia; Faculty of Sciences of Bizerte, Zarzouna 702, University of Carthage, Tunisia., Gorsane F; Laboratory of Molecular Genetics, Immunology and Biotechnology, Faculty of Sciences of Tunis, University of Tunis El Manar, Tunis 2092, Tunisia; Faculty of Sciences of Bizerte, Zarzouna 702, University of Carthage, Tunisia. Electronic address: faten.gorsane@fsb.u-carthage.tn.
Jazyk: angličtina
Zdroj: Gene [Gene] 2021 Dec 15; Vol. 804, pp. 145905. Date of Electronic Publication: 2021 Aug 16.
DOI: 10.1016/j.gene.2021.145905
Abstrakt: Tomato spotted wilt virus (TSWV) causes severe losses of tomato crops worldwide. To cope dynamically with such a threat, plants deploy strategies acting at the molecular and the epigenetic levels. We found that tomato symptoms progress in a specific-genotype-manner upon TSWV infection. Susceptible genotypes showed within the Auxin Response Factor (ARF8) promoter coupled to enhanced expression of miRNA167a, reduced ARF8 gene and decreased levels of the hormone auxin. This constitutes a deliberate attempt of TSWV to disrupt plant growth to promote spread in sensitive cultivars. Epigenetic regulation through the level of cytosine methylation and the miR167a-ARF8 module are part of a complex network modulating auxin-triggered synthesis and shaping tomato responses to TSWV. Furthermore, modulation of miR167a-ARF8 regulatory module could be applied in tomato-resistance breeding programs.
(Copyright © 2021 Elsevier B.V. All rights reserved.)
Databáze: MEDLINE
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