Non-Animal Stabilized Hyaluronic Acid/Dextranomer Gel (NASHA/Dx, Deflux) for Endoscopic Treatment of Vesicoureteral Reflux: What Have We Learned Over the Last 20 Years?

Autor: Kirsch AJ; Pediatric Urology, Children's Healthcare of Atlanta and Emory University School of Medicine, Atlanta, GA. Electronic address: akirschmd@gmail.com., Cooper CS; Department of Urology, University of Iowa, Iowa City, IA., Läckgren G; Section of Urology, University Children´s Hospital, Uppsala, SE.
Jazyk: angličtina
Zdroj: Urology [Urology] 2021 Nov; Vol. 157, pp. 15-28. Date of Electronic Publication: 2021 Aug 16.
DOI: 10.1016/j.urology.2021.07.032
Abstrakt: Non-animal stabilized hyaluronic acid/dextranomer gel (Deflux; NASHA/Dx) was developed as a treatment for vesicoureteral reflux (VUR) in the 1990s. To mark 20 years since the US approval of this agent, we reviewed its properties, best practice for application, and the available clinical safety and efficacy data. Long-term or randomized, controlled studies of treatment with NASHA/Dx have reported VUR resolution rates of 59%-100% with low rates of febrile urinary tract infection post-treatment (4%-25%), indicating long-term protection of the kidneys. An individualized approach VUR management is advocated, and NASHA/Dx is a viable option for many patients requiring intervention.
(Copyright © 2021 The Authors. Published by Elsevier Inc. All rights reserved.)
Databáze: MEDLINE