Selective Magnetic Nanoheating: Combining Iron Oxide Nanoparticles for Multi-Hot-Spot Induction and Sequential Regulation.

Autor:	Ovejero JG; Institute of Materials Science of Madrid (ICMM-CSIC), Sor Juana Inés de la Cruz 3, 28049 Madrid, Spain., Armenia I; BioNanoSurf Group, Aragon Nanoscience and Materials Institute (INMA-CSIC-UNIZAR), Edificio I+D, Mariano Esquillor Gómez, 50018 Zaragoza, Spain., Serantes D; Applied Physics Department and Instituto de Investigacións Tecnolóxicas, Universidade de Santiago de Compostela, 15782 Santiago de Compostela, Spain., Veintemillas-Verdaguer S; Institute of Materials Science of Madrid (ICMM-CSIC), Sor Juana Inés de la Cruz 3, 28049 Madrid, Spain., Zeballos N; Heterogeneous Biocatalysis Laboratory, Center for Cooperative Research in Biomaterials (CIC biomaGUNE), Basque Research and Technology Alliance, Paseo de Miramón 194, 20014 Donostia-San Sebastián, Spain.; IKERBASQUE, Basque Foundation for Science, María Díaz de Haro 3, 48013 Bilbao, Spain., López-Gallego F; Heterogeneous Biocatalysis Laboratory, Center for Cooperative Research in Biomaterials (CIC biomaGUNE), Basque Research and Technology Alliance, Paseo de Miramón 194, 20014 Donostia-San Sebastián, Spain.; IKERBASQUE, Basque Foundation for Science, María Díaz de Haro 3, 48013 Bilbao, Spain., Grüttner C; Micromod, Partikeltechnologie GmbH, Friedrich-Barnewitz-Straße 4, 18119 Rostock, Germany., de la Fuente JM; BioNanoSurf Group, Aragon Nanoscience and Materials Institute (INMA-CSIC-UNIZAR), Edificio I+D, Mariano Esquillor Gómez, 50018 Zaragoza, Spain.; Centro de Investigación Biomédica en Red de Bioingeniería, Biomateriales y Nanomedicina (CIBER-BBN), Avenida Monforte de Lemos, 3-5, 28029 Madrid, Spain., Puerto Morales MD; Institute of Materials Science of Madrid (ICMM-CSIC), Sor Juana Inés de la Cruz 3, 28049 Madrid, Spain., Grazu V; BioNanoSurf Group, Aragon Nanoscience and Materials Institute (INMA-CSIC-UNIZAR), Edificio I+D, Mariano Esquillor Gómez, 50018 Zaragoza, Spain.; Centro de Investigación Biomédica en Red de Bioingeniería, Biomateriales y Nanomedicina (CIBER-BBN), Avenida Monforte de Lemos, 3-5, 28029 Madrid, Spain.
Jazyk:	angličtina
Zdroj:	Nano letters [Nano Lett] 2021 Sep 08; Vol. 21 (17), pp. 7213-7220. Date of Electronic Publication: 2021 Aug 19.
DOI:	10.1021/acs.nanolett.1c02178
Abstrakt:	The contactless heating capacity of magnetic nanoparticles (MNPs) has been exploited in fields such as hyperthermia cancer therapy, catalysis, and enzymatic thermal regulation. Herein, we propose an advanced technology to generate multiple local temperatures in a single-pot reactor by exploiting the unique nanoheating features of iron oxide MNPs exposed to alternating magnetic fields (AMFs). The heating power of the MNPs depends on their magnetic features but also on the intensity and frequency conditions of the AMF. Using a mixture of diluted colloids of MNPs we were able to generate a multi-hot-spot reactor in which each population of MNPs can be selectively activated by adjusting the AMF conditions. The maximum temperature reached at the surface of each MNP was registered using independent fluorescent thermometers that mimic the molecular link between enzymes and MNPs. This technology paves the path for the implementation of a selective regulation of multienzymatic reactions.
Databáze:	MEDLINE
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