Effect of pattern scanning laser on macular thickness in diabetic retinopathy.
| Autor: | Hamed N; Department of Ophthalmology, College of Medicine, University of Florida, Gainesville, FL, USA., Vander Woude L; Department of Ophthalmology, College of Medicine, University of Florida, Gainesville, FL, USA., Roohipourmoallai R; Department of Ophthalmology, College of Medicine, University of Florida, Gainesville, FL, USA., Ohning C; Department of Ophthalmology, College of Medicine, University of Florida, Gainesville, FL, USA., Regan KA; Department of Ophthalmology, College of Medicine, University of Florida, Gainesville, FL, USA., Iyer SSR; Associate Professor, Department of Ophthalmology, College of Medicine , University of Florida, 1600, SW Archer Road, Gainesville FL, 32610, USA. |
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| Jazyk: | angličtina |
| Zdroj: | Therapeutic advances in ophthalmology [Ther Adv Ophthalmol] 2021 Aug 12; Vol. 13, pp. 25158414211035860. Date of Electronic Publication: 2021 Aug 12 (Print Publication: 2021). |
| DOI: | 10.1177/25158414211035860 |
| Abstrakt: | Purpose: This study investigates the effect of pattern scanning laser (PASCAL) panretinal photocoagulation (PRP) on central macular thickness (CMT) and visual acuity (VA) in patients with proliferative diabetic retinopathy (PDR). Methods: This retrospective non-randomized comparative case series included 262 eyes (163 with macular edema) of 177 patients with PDR. Treatment was PRP alone (137), PRP + anti-vascular endothelial growth factor (VEGF) (69), PRP + focal laser (28), or all three (89). CMT and central macular volume 3 and 6 mm from fovea were analyzed before and 1, 3, and 6 months after PRP. Spot number was plotted against CMT, and linear regression analysis was performed. Results: For each treatment group and time point, there was a non-significant relationship between spot number and CMT. In eyes receiving all three treatment modalities, a significant negative relationship was found between spot number and 3-mm volume at 6 months ( p = 0.04) and 6-mm volume at 1 month ( p = 0.002) and 6 months ( p = 0.011). There was no significant change in VA in any treatment group at the 6-month time point. Conclusion: PASCAL PRP ± focal laser or anti-VEGF was not associated with increased development of macular edema or change in VA. PASCAL PRP with focal laser and anti-VEGF may result in a decrease in macular edema. Competing Interests: Conflict of interest statement: The authors declared no potential conflicts of interest with respect to the research, authorship, and/or publication of this article. (© The Author(s), 2021.) |
| Databáze: | MEDLINE |
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