Very low prevalence of ultrasound-detected tenosynovial abnormalities in healthy subjects throughout the age range: OMERACT ultrasound minimal disease study.

Autor:	Trickey J; Institute of Inflammation and Ageing, University of Birmingham, Birmingham, UK.; NIHR Birmingham Biomedical Reserarch Centre, University Hospitals Birmingham NHS Foundation Trust, Birmingham, UK., Sahbudin I; Institute of Inflammation and Ageing, University of Birmingham, Birmingham, UK.; NIHR Birmingham Biomedical Reserarch Centre, University Hospitals Birmingham NHS Foundation Trust, Birmingham, UK., Ammitzbøll-Danielsen M; Center for Rheumatology and Spine Diseases, Rigshospitalet, Copenhagen, Denmark., Azzolin I; Academic Rheumatology Center, MFRU, Department of Clinical and Biological Science, University of Turin, Turin, Italy., Borst C; Department of Dermatology, Medical University of Vienna, Vienna, Austria., Bortoluzzi A; Section of Rheumatology, Department of Medical Sciences, University of Ferrara and Azienda Ospedaliera-Universitaria di Ferrara, Cona, Italy., Bruyn GA; MC Hospital Group, Lelystad, Netherlands.; Reumakliniek Flevoland, Lelystad, Netherlands., Carron P; Department of Internal Medicine and Paediatrics, University Hospital Ghent, Ghent, Belgium.; VIB Center for Inflammation Research, Ghent University, Ghent, Belgium., Ciurtin C; Centre for Adolescent Rheumatology, Division of Medicine, University College London, London, UK., Filippou G; University Hospital, Rheumatology Unit, ASST Fatebenefratelli Sacco, Milan, Italy., Fliciński J; Department of Internal Medicine, Rheumatology, Diabetes, Geriatrics and Clinical Immunology, Pomeranian Medical University, Szczecin, Poland., Fodor D; 2nd Internal Medicine, UMF Iuliu Haţieganu Cluj-Napoca, Cluj-Napoca, Romania., Gouze H; Hopital Ambroise-Pare, Boulogne-Billancourt, France., Gutierrez M; Clinica Reumatologica, Università Politecnica delle Marche, Ancona, Italy.; Instituto Nacional de Rehabilitacion Luis Guillermo Ibarra Ibarra, Mexico, Mexico., Hammer HB; Rheumatology, Diakonhjemmet Sykehus, Oslo, Norway.; Faculty of Medicine, University of Oslo, Oslo, Norway., Hauge EM; Department of Rheumatology, Aarhus University Hospital, Aarhus, Denmark.; Department of Clinical Medicine, Aarhus University, Aarhus, Denmark., Iagnocco A; Academic Rheumatology Centre, Università degli Studi di Torino, Turin, Italy., Ikeda K; Department of Allergy and Clinical Immunology, Chiba University Hospital, Chiba, Japan., Karalilova R; University Hospital Kaspela, Medical University of Plovdiv Hospital, Plovdiv, Bulgaria., Keen HI; Medicine and Pharmacology, UWA, Perth, WA, Australia., Kortekaas M; Leiden University Medical Center, Leiden, Netherlands.; Flevoziekenhuis, Almere, Netherlands., La Paglia G; Rheumatology Unit, Asst-Fbf-Sacco, Luigi Sacco Hospital, Milan, Italy., Leon G; Instituto Nacional de Rehabilitacion, Mexico, Mexico.; Hospital Nacional Edgardo Rebagliati Martins, Lima, Peru., Mandl P; Department of Rheumatology, Medical University of Vienna, Vienna, Austria., Maruseac M; Department of Rheumatology, Cliniques universitaires Saint-Luc, Brussels, Belgium., Milchert M; Department of Internal Medicine, Rheumatology, Diabetes, Geriatrics and Clinical Immunology, Pomeranian Medical University, Szczecin, Poland., Mortada MA; Department of Rheumatology Rehabilitation and Physical Medicine, Zagazig University, Zagazig, Egypt., Naredo E; Rheumatology, Hospital Universitario Fundación Jiménez Díaz, Madrid, Spain., Ohrndorf S; Department of Rheumatology and Clinical Immunology, Charité-Universitätsmedizin Berlin, Campus Mitte, Humboldt-Universität zu Berlin, Freie Universität Berlin, Berlin, Germany., Pineda C; Rheumatology, Instituto Nacional de Rehabilitación Luis Guillermo Ibarra Ibarra, Mexico, Mexico., Rasch MNB; Department of Rheumatology, Aarhus University Hospital, Aarhus, Denmark., Reátegui-Sokolova C; Rheumatology, Instituto Nacional de Rehabilitación Luis Guillermo Ibarra Ibarra, Mexico, Mexico.; Universidad San Ignacio de Loyola, Lima, Peru., Sakellariou G; Istituti Clinici Scientifici Maugeri SpA SB IRCCS, Pavia, Italy., Serban T; S.C. Reumatologia, ASL3 Genovese, Ospedale La Colletta, Genoa, Italy., Sifuentes-Cantú CA; Hospital Universitario Fundación Jiménez Díaz, Madrid, Spain.; Department of Immunology and Rheumatology, Instituto Nacional de Ciencias Medicas y Nutricion Salvador Zubiran, Tlalpan, Mexico., Stoenoiu MS; Institut de Recherche Expérimentale et Clinique, Université catholique de Louvain, Rheumatology Department, Cliniques universitaires Saint-Luc, Brussels, Belgium., Suzuki T; Division of Allergy and Rheumatology, Japanese Red Cross Medical Center, Shibuya, Japan., Terslev L; Center for Rheumatology and Spine Diseases, Rigshospitalet, Copenhagen, Denmark., Tinazzi I; Unit of Rheumatology, IRCCS Ospedale Sacro Cuore Don Calabria, Negrar, Italy., Vreju FA; Department of Rheumatology, University of Medicine and Pharmacy of Craiova, Craiova, Romania., Wittoek R; VIB Center for Inflammation Research, Ghent University, Ghent, Belgium.; Department of Internal Medicine and Paediatrics, Ghent University, Ghent, Belgium., D'Agostino MA; Università Cattolica del Sacro Cuore, Fondazione Policlinico Universitario Agostino Gemelli IRCCS, Roma, Italy., Filer A; Institute of Inflammation and Ageing, University of Birmingham, Birmingham, UK a.filer@bham.ac.uk.; NIHR Birmingham Biomedical Reserarch Centre, University Hospitals Birmingham NHS Foundation Trust, Birmingham, UK.
Jazyk:	angličtina
Zdroj:	Annals of the rheumatic diseases [Ann Rheum Dis] 2022 Feb; Vol. 81 (2), pp. 232-236. Date of Electronic Publication: 2021 Aug 18.
DOI:	10.1136/annrheumdis-2021-219931
Abstrakt:	Objectives: This study aimed to determine the prevalence of ultrasound-detected tendon abnormalities in healthy subjects (HS) across the age range. Methods: Adult HS (age 18-80 years) were recruited in 23 international Outcome Measures in Rheumatology ultrasound centres and were clinically assessed to exclude inflammatory diseases or overt osteoarthritis before undergoing a bilateral ultrasound examination of digit flexors (DFs) 1-5 and extensor carpi ulnaris (ECU) tendons to detect the presence of tenosynovial hypertrophy (TSH), tenosynovial power Doppler (TPD) and tenosynovial effusion (TEF), usually considered ultrasound signs of inflammatory diseases. A comparison cohort of patients with rheumatoid arthritis (RA) was taken from the Birmingham Early Arthritis early arthritis inception cohort. Results: 939 HS and 144 patients with RA were included. The majority of HS (85%) had grade 0 for TSH, TPD and TEF in all DF and ECU tendons examined. There was a statistically significant difference in the proportion of TSH and TPD involvement between HS and subjects with RA (HS vs RA p<0.001). In HS, there was no difference in the presence of ultrasound abnormalities between age groups. Conclusions: Ultrasound-detected TSH and TPD abnormalities are rare in HS and can be regarded as markers of active inflammatory disease, especially in newly presenting RA. Competing Interests: Competing interests: There are no declared competing interests from authors except the following: CC declared grants from NIHR Versus Arthritis, Lilly sponsored EULAR conference travel, Modern Biosciences payment as DSM committee member, Roche consultancy fee and Novartis sponsored writing of one medical paper. KI declared a Mitsubishi-Tanabe research grant for RA; Abbvie, Eli Lilly, Mitsubishi-Tanabe, Bristol-Myers-Squib and Novartis speaker’s fees; and participation on a DSM board for Abbvie, Eli Lilly and Mitsubishi-Tanabe. RK declared support from Abbvie, Roche, Novartis and UCB with payments for travel to meetings/lectures, presentations, speakers’ bureaus, manuscript writing/educational events. (© Author(s) (or their employer(s)) 2022. Re-use permitted under CC BY. Published by BMJ.)
Databáze:	MEDLINE
Externí odkaz:	Zobrazit plný text záznamu