Wound healing and dermal regeneration in severe burn patients treated with NovoSorb® Biodegradable Temporising Matrix: A prospective clinical study.

Autor: Lo CH; Victorian Adult Burns Service, The Alfred, 55 Commercial Rd, Melbourne, VIC 3004, Australia; Department of Surgery, Central Clinical School, Monash University, 99 Commercial Rd, Melbourne, VIC 3004, Australia. Electronic address: c.lo@alfred.org.au., Brown JN; Professor Stuart Pegg Adult Burns Centre, Royal Brisbane and Women's Hospital, Butterfield St, Herston, QLD 4029, Australia. Electronic address: Jason.brown@health.qld.gov.au., Dantzer EJG; Centre des Brûlés, Hôpital d'Instruction des Armées Sainte-Anne, 2 Boulevard Sainte-Anne, 83000, Toulon, France. Electronic address: eric.dantzer@wanadoo.fr., Maitz PKM; Burns Unit, Concord Repatriation General Hospital, Hospital Road, Concord, NSW 2139, Australia. Electronic address: peter.maitz@sydney.edu.au., Vandervord JG; Department of Burns, Reconstructive and Plastic Surgery, Royal North Shore Hospital, Reserve Road, St. Leonards, NSW 2065, Australia. Electronic address: johnvandervord@bigpond.com., Wagstaff MJD; Adult Burns Service and Department of Plastic and Reconstructive Surgery, Royal Adelaide Hospital, Port Rd, Adelaide, SA 5000, Australia. Electronic address: m.wagstaff@doctors.org.uk., Barker TM; PolyNovo Biomaterials Pty Ltd., 2/320 Lorimer Street, Port Melbourne, VIC 3207, Australia. Electronic address: tim.b@polynovo.com., Cleland H; Victorian Adult Burns Service, The Alfred, 55 Commercial Rd, Melbourne, VIC 3004, Australia; Department of Surgery, Central Clinical School, Monash University, 99 Commercial Rd, Melbourne, VIC 3004, Australia. Electronic address: h.cleland@alfred.org.au.
Jazyk: angličtina
Zdroj: Burns : journal of the International Society for Burn Injuries [Burns] 2022 May; Vol. 48 (3), pp. 529-538. Date of Electronic Publication: 2021 Jul 31.
DOI: 10.1016/j.burns.2021.07.014
Abstrakt: Introduction: For extensive burns, autologous donor skin may be insufficient for early debridement and grafting in a single stage. A novel, synthetic polyurethane dermal template (NovoSorb® Biodegradable Temporising Matrix, BTM) was developed to address this need. The aim of this study was to evaluate use of BTM for primary dermal repair after deep burn injury.
Methods: A multicentre, prospective, clinical study was conducted from September 2015 to May 2018. The primary endpoint was % split skin graft take over applied BTM at 7-10 days after grafting. Secondary endpoints included % BTM take, incidence of infection and adverse events, and scar quality to 12 months after BTM application.
Results: Thirty patients were treated with BTM and delayed split skin grafting. The % graft take had a mean of 81.9% and % BTM take had a mean of 88.6%, demonstrating effective integration of BTM. When managed appropriately, it was possible for BTM to integrate successfully despite findings suggestive of infection. Scar quality improved over time.
Discussion: These results provide additional clinical evidence on the safety and performance of BTM as an effective dermal substitute in the treatment of patients with deep burn injuries.
(Copyright © 2021 The Authors. Published by Elsevier Ltd.. All rights reserved.)
Databáze: MEDLINE
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