Erythropoietin is not a risk factor for severe retinopathy of prematurity among high risk preterm infants.

Autor: Bui KCT; Department of Pediatrics, Kaiser Permanente Los Angeles, California, United States of America. Electronic address: Kim-chi.T.Bui@kp.org., Ellenhorn N; Department of Ophthalmology, Kaiser Permanente Los Angeles, California, United States of America., Abbasi A; Department of Pediatrics, Kaiser Permanente Downey, California, United States of America., Villosis MFB; Department of Pediatrics, Kaiser Permanente Panorama City, California, United States of America., Nguyen M; Department of Pediatrics, Kaiser Permanente Orange County, California, United States of America., Truong H; Department of Pediatrics, Kaiser Permanente Fontana, California, United States of America., Watson T; Department of Pediatrics, Kaiser Permanente Los Angeles, California, United States of America., Buchanan J; Department of Pediatrics, Kaiser Permanente Los Angeles, California, United States of America., Chen Q; Department of Research and Evaluation, Kaiser Permanente Southern California, Pasadena, California, United States of America.
Jazyk: angličtina
Zdroj: Early human development [Early Hum Dev] 2021 Oct; Vol. 161, pp. 105440. Date of Electronic Publication: 2021 Aug 08.
DOI: 10.1016/j.earlhumdev.2021.105440
Abstrakt: Background: Retinopathy of prematurity (ROP) is a developmental retinal vaso-proliferative disease and a leading cause of blindness in children. Early gestational age, low birth weight and unregulated oxygen exposure are the main risk factors for the development of ROP. There are conflicting reports of a possible association between recombinant Erythropoietin (rhEPO) use and an increased risk for the development of ROP.
Objective: To determine whether rhEPO is an independent risk factor for the development of severe ROP among preterm infants with a gestational age of 23 to 32 weeks and a birth weight <1500 g.
Methods: We performed a retrospective study of risk factors for ROP on a cohort of 1762 premature infants born between 2009 and 2014, half of whom received rhEPO. To examine the association between treated ROP and rhEPO, a propensity score (PS) analysis was performed using the inverse probability of treatment weighted (IPTW) approach.
Results: The incidence of treated ROP was 7.3% (129/1762). PS analysis did not show an association between rhEPO and severe ROP needing treatment or ROP stage 2 or higher, in either the whole population or in the subgroup of babies born at 23 to 28 weeks gestation, in whom the incidence of severe ROP was the highest. Of 117 patients treated for Type 1 or worsening stage 3 ROP, 17 were first diagnosed after NICU discharge.
Conclusion: Our study showed no association between Erythropoietin use and severe ROP and highlights the importance of Ophthalmology follow up after hospital discharge.
(Copyright © 2021 The Authors. Published by Elsevier B.V. All rights reserved.)
Databáze: MEDLINE
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