Autophagy impairment by African swine fever virus.

Autor:	Shimmon GL; The Pirbright Institute, Ash Road, Pirbright, Woking, Surrey GU24 0NF, UK., Hui JYK; The Pirbright Institute, Ash Road, Pirbright, Woking, Surrey GU24 0NF, UK., Wileman TE; Biomedical Research Centre, University of East Anglia, Norwich Research Park, Norwich NR4 7TJ, UK.; Quadram Institute, Norwich Research Park, Norwich, Norfolk, NR4 7UQ, UK., Netherton CL; The Pirbright Institute, Ash Road, Pirbright, Woking, Surrey GU24 0NF, UK.
Jazyk:	angličtina
Zdroj:	The Journal of general virology [J Gen Virol] 2021 Aug; Vol. 102 (8).
DOI:	10.1099/jgv.0.001637
Abstrakt:	African swine fever is a devastating disease of domestic swine and wild boar caused by a large double-stranded DNA virus that encodes for more than 150 open reading frames. There is no licensed vaccine for the disease and the most promising current candidates are modified live viruses that have been attenuated by deletion of virulence factors. Like many viruses African swine fever virus significantly alters the host cell machinery to benefit its replication and viral genes that modify host pathways represent promising targets for development of gene deleted vaccines. Autophagy is an important cellular pathway that is involved in cellular homeostasis, innate and adaptive immunity and therefore is manipulated by a number of different viruses. Autophagy is regulated by a complex protein cascade and here we show that African swine fever virus can block formation of autophagosomes, a critical functional step of the autophagy pathway through at least two different mechanisms. Interestingly this does not require the A179L gene that has been shown to interact with Beclin-1, an important autophagy regulator.
Databáze:	MEDLINE
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