| Autor: |
Lee OS; Qatar Environment and Energy Research Institute, Hamad Bin Khalifa University, PO Box 34110 Doha, Qatar., Madjet ME; Max-Planck-Institut für Physik, Komplexer Systeme, Nöthnitzer Straße 38, 01187 Dresden, Germany., Mahmoud KA; Qatar Environment and Energy Research Institute, Hamad Bin Khalifa University, PO Box 34110 Doha, Qatar. |
| Jazyk: |
angličtina |
| Zdroj: |
Nano letters [Nano Lett] 2021 Oct 13; Vol. 21 (19), pp. 8510-8517. Date of Electronic Publication: 2021 Aug 17. |
| DOI: |
10.1021/acs.nanolett.1c01986 |
| Abstrakt: |
MXenes, two-dimensional metal carbides or nitrides with multifunctional surfaces, are one of the most promising antibacterial nanoscale materials. However, their putative bactericidal mechanism is elusive. To study their bactericidal mechanism, we investigated the interaction between a MXene nanosheet and a model bacterial membrane by molecular dynamics simulations and found that an adsorbed MXene on a membrane surface induced a local phase transition in a domain where the fluidity of the phospholipid in this domain at room temperature was comparable with that of the gel phase. The domain also showed a denser and thinner phospholipid membrane structure than the peripheral phospholipids. By comparing it with our previous experiments of the bactericidal activity of MXenes, we proposed the leakage of intercellular molecules at the phase boundary defects as a possible bactericidal mechanism of MXenes that leads to cell lysis. This study provides a useful model for tailoring new bactericidal nanomaterials. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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