Maternal serum uric acid: a reliable prognostic indicator of foetal outcome among pre-eclamptic patients in a low resource setting.
| Autor: | Ayankunle OM; Department of Obstetrics and Gynaecology, College of Medicine and Health Sciences, Afe Babalola University/Federal Teaching Hospital, Ido-Ekiti, Nigeria., Adeniyi AA; Department of Obstetrics and Gynaecology, College of Medicine and Health Sciences, Afe Babalola University/Federal Teaching Hospital, Ido-Ekiti, Nigeria., Adewara OE; Department of Obstetrics and Gynaecology, College of Medicine and Health Sciences, Afe Babalola University/Federal Teaching Hospital, Ido-Ekiti, Nigeria., Awoyinka SB; Department of Obstetrics and Gynaecology, College of Medicine and Health Sciences, Afe Babalola University/Federal Teaching Hospital, Ido-Ekiti, Nigeria., Adebara IO; Department of Obstetrics and Gynaecology, College of Medicine and Health Sciences, Afe Babalola University/Federal Teaching Hospital, Ido-Ekiti, Nigeria., Adeyemo OT; Department of Obstetrics and Gynaecology, College of Medicine and Health Sciences, Afe Babalola University/Federal Teaching Hospital, Ido-Ekiti, Nigeria., Bakare A; Department of Obstetrics and Gynaecology, College of Medicine and Health Sciences, Afe Babalola University/Federal Teaching Hospital, Ido-Ekiti, Nigeria., Olumodeji AM; Institute of Maternal and Child Health, Lagos State University Teaching Hospital, Lagos, Nigeria., Jimoh AK; Department of Chemical pathology, College of Medicine and Health Sciences, Afe Babalola University/Federal Teaching Hospital, Ido-Ekiti, Nigeria. |
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| Jazyk: | angličtina |
| Zdroj: | The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians [J Matern Fetal Neonatal Med] 2022 Dec; Vol. 35 (25), pp. 7695-7700. Date of Electronic Publication: 2021 Aug 17. |
| DOI: | 10.1080/14767058.2021.1960969 |
| Abstrakt: | Background: Pre-eclampsia is a major cause of maternal and fetal morbidity and mortality in both developed and developing countries. Hyperuricemia is often associated with pre-eclampsia and when this occurs, fetal outcome may become worse. We evaluated the role of maternal serum uric acid as a prognostic indicator of fetal outcome in pre-eclamptic mothers. Methods: A prospective case-control study in which 55 eligible pre-eclamptic patients at term were matched in maternal age and gestational age with 55 consecutive normotensive pregnant women. Venous blood samples were obtained and analyzed for serum uric acid. Following delivery, the fetal outcomes in the pre-eclamptic group and controls were determined. Data analysis was carried out using SPSS (version 21) and the level of statistical significance was set at p -value <.05. Results: The mean serum uric acid levels of the pre-eclamptic subjects was significantly higher compared to their normotensive counterparts (12.7 ± 7.8 vs. 4.9 ± 1.2 mg/dL, p = .000). Babies with low birth weight, poor Apgar scores (at 1st and 5th minute of life) and those who required neonatal unit admission occurred more significantly among the pre-eclamptic women when compared with the controls ( p = .000). However, the live birth rate of the case and control groups was comparable (94.5% vs. 100%, p = .079), Binary logistic regression analysis revealed a positive association between hyperuricemia and pre-eclampsia (OR = 18.8; 95% CI = 1.22-289.35, p = .035). Pre-eclamptic mothers with hyperuricemia had 4.41 odds of delivering babies with low birth weight when compared with pre-eclamptics without hyperuricemia (OR = 4.41; 95% CI = 0.76-25.5, p = .097); but Apgar scores and need for neonatal admission showed no association with maternal serum uric acid levels. Conclusion: This study therefore suggests that hyperuricemia is a strong prognostic indicator of LBW babies among women with pre-eclampsia. |
| Databáze: | MEDLINE |
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