Cisplatin ototoxicity histopathology.

Autor: Hodge SE; House Ear Clinic Los Angeles California USA., Lopez IA; Department of Head and Neck Surgery David Geffen School of Medicine at UCLA Los Angeles California USA., Ishiyama G; Department of Neurology David Geffen School of Medicine at UCLA Los Angeles California USA., Ishiyama A; Department of Head and Neck Surgery David Geffen School of Medicine at UCLA Los Angeles California USA.
Jazyk: angličtina
Zdroj: Laryngoscope investigative otolaryngology [Laryngoscope Investig Otolaryngol] 2021 Jun 28; Vol. 6 (4), pp. 852-856. Date of Electronic Publication: 2021 Jun 28 (Print Publication: 2021).
DOI: 10.1002/lio2.608
Abstrakt: This study investigates the histopathological changes of the cochlea and vestibular end organs of a patient who received cisplatin for Hodgkin's lymphoma. He experienced acute high-frequency sensorineural hearing loss and tinnitus after receiving treatment. Using histopathological analysis of his temporal bones after he unfortunately succumbed to his disease, we found that the ototoxic effect of cisplatin is primarily within the cochlea, with significant damage located at the organ of Corti at the base-hook region, consistent with findings in animal models. The effects of cisplatin were minimal when reviewing the vestibular end organs.
Competing Interests: The authors declare no conflict of interest to report.
(© 2021 The Authors. Laryngoscope Investigative Otolaryngology published by Wiley Periodicals LLC on behalf of The Triological Society.)
Databáze: MEDLINE
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