Cardioprotective 22-hydroxylanostane triterpenoids from the fruiting bodies of Phellinus igniarius.

Autor: Li YT; Guangdong Provincial Key Laboratory of New Drug Screening, School of Pharmaceutical Sciences, Southern Medical University, Guangzhou, 510515, People's Republic of China., Zhang Z; School of Traditional Chinese Medicine, Guangdong Pharmaceutical University, Guangzhou, 510006, People's Republic of China., Feng Y; Griffith Institute for Drug Discovery, Griffith University, Brisbane, 4111, Australia., Cheng Y; School of Pharmaceutical Sciences, Guangzhou University of Chinese Medicine, Guangzhou, 510006, People's Republic of China., Li S; School of Traditional Chinese Medicine, Guangdong Pharmaceutical University, Guangzhou, 510006, People's Republic of China., Li C; Central Laboratory, Southern Medical University, Guangzhou, 510515, People's Republic of China., Tian LW; Guangdong Provincial Key Laboratory of New Drug Screening, School of Pharmaceutical Sciences, Southern Medical University, Guangzhou, 510515, People's Republic of China. Electronic address: lwtian@smu.edu.cn.
Jazyk: angličtina
Zdroj: Phytochemistry [Phytochemistry] 2021 Nov; Vol. 191, pp. 112907. Date of Electronic Publication: 2021 Aug 13.
DOI: 10.1016/j.phytochem.2021.112907
Abstrakt: Seven undescribed 22-hydroxylanostane triterpenoids were isolated from the fruiting bodies of Phellinus igniarius, together with three known sterols. Their structures were assigned by extensive spectroscopic and HRESIMS data analyses. The absolute configurations of C-22 were determined by X-ray crystallography, chemical methods, and spectroscopic data comparison. Phellinol G was a 25,26,27-trinorlanostane triterpenoid glycoside. 22S/22R-25,26,27- Trinorlanosta-8-en-3β,22,24-triols with the same side chain as that of phellinol G were stereoselectively synthesized from commercial lanosterol for the first time. The key step involved Sharpless asymmetrical epoxidation. Phellinols A, B, and F showed cardioprotective activity against oxygen-glucose deprivation/reoxygenation injury in H9c2 cells at a concentration of 20 μM.
(Copyright © 2021 Elsevier Ltd. All rights reserved.)
Databáze: MEDLINE
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