Attachment of cartilage wear particles to the synovium negatively impacts friction properties.

Autor: Estell EG; Columbia University, Department of Biomedical Engineering, New York, NY, United States., Murphy LA; Columbia University, Department of Biomedical Engineering, New York, NY, United States., Gangi LR; Columbia University, Department of Biomedical Engineering, New York, NY, United States., Shah RP; Columbia University, Department of Orthopedic Surgery, New York, NY, United States., Ateshian GA; Columbia University, Department of Biomedical Engineering, New York, NY, United States; Columbia University, Department of Mechanical Engineering, New York, NY, United States., Hung CT; Columbia University, Department of Biomedical Engineering, New York, NY, United States; Columbia University, Department of Orthopedic Surgery, New York, NY, United States. Electronic address: cth6@columbia.edu.
Jazyk: angličtina
Zdroj: Journal of biomechanics [J Biomech] 2021 Oct 11; Vol. 127, pp. 110668. Date of Electronic Publication: 2021 Aug 04.
DOI: 10.1016/j.jbiomech.2021.110668
Abstrakt: Cartilage wear particles are released into the synovial fluid by mechanical and chemical degradation of the articular surfaces during osteoarthritis and attach to the synovial membrane. Accumulation of wear particles could alter key tissue-level mechanical properties of the synovium, hindering its characteristically low-friction interactions with underlying articular surfaces in the synovial joint. The present study employs a custom loading device to further the characterization of native synovium friction properties, while investigating the hypothesis that attachment of cartilage wear particles increases friction coefficient. Juvenile bovine synovium demonstrated characteristically low friction coefficients in sliding contact with glass, in agreement with historical measurements. Friction coefficient increased with higher normal load in saline, while lubrication with native synovial fluid maintained low friction coefficients at higher loads. Cartilage wear particles generated from juvenile bovine cartilage attached directly to synovium explants in static culture, with incorporation onto the tissue denoted by cell migration onto the particle surface. In dilute synovial fluid mimicking the decreased lubricating properties during osteoarthritis, wear particle attachment significantly increased friction coefficient against glass, and native cartilage and synovium. In addition to providing a novel characterization of synovial joint tribology this work highlights a potential mechanism for cartilage wear particles to perpetuate the degradative environment of osteoarthritis by modulating tissue-level properties of the synovium that could impact macroscopic wear as well as mechanical stimuli transmitted to resident cells.
(Copyright © 2021 Elsevier Ltd. All rights reserved.)
Databáze: MEDLINE
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