Distinct Cytokine and Chemokine Dysregulation in Hospitalized Children With Acute Coronavirus Disease 2019 and Multisystem Inflammatory Syndrome With Similar Levels of Nasopharyngeal Severe Acute Respiratory Syndrome Coronavirus 2 Shedding.

Autor:	Peart Akindele N; Johns Hopkins University, School of Medicine, Department of Pediatrics, Division of Pediatric Infectious Diseases, Baltimore, Maryland, USA., Kouo T; Johns Hopkins University, School of Medicine, Department of Pediatrics, Division of Pediatric Emergency Medicine, Baltimore, Maryland, USA., Karaba AH; Johns Hopkins University, School of Medicine, Department of Medicine, Division of Infectious Diseases, Baltimore, Maryland, USA., Gordon O; Johns Hopkins University, School of Medicine, Department of Pediatrics, Division of Pediatric Infectious Diseases, Baltimore, Maryland, USA., Fenstermacher KZJ; Johns Hopkins University, School of Medicine, Department of Emergency Medicine, Baltimore, Maryland, USA., Beaudry J; Johns Hopkins University, School of Medicine, Department of Pediatrics, Division of Pediatric Infectious Diseases, Baltimore, Maryland, USA., Rubens JH; Johns Hopkins University, School of Medicine, Department of Pediatrics, Division of Pediatric Infectious Diseases, Baltimore, Maryland, USA., Atik CC; Johns Hopkins University, School of Medicine, Baltimore, Maryland, USA., Zhou W; Johns Hopkins Bloomberg School of Public Health, Department of Biostatistics, Baltimore, Maryland, USA., Ji H; Johns Hopkins Bloomberg School of Public Health, Department of Biostatistics, Baltimore, Maryland, USA., Tao X; Johns Hopkins University, School of Medicine, Department of Pediatrics, Baltimore, Maryland, USA., Vaidya D; Johns Hopkins University, School of Medicine, Department of Medicine, Baltimore, Maryland, USA., Mostafa H; Johns Hopkins University, School of Medicine, Department of Pathology, Division of Medical Microbiology, Baltimore, Maryland, USA., Caturegli P; Johns Hopkins University, School of Medicine, Baltimore, Maryland, USA., Blair PW; Johns Hopkins University, School of Medicine, Department of Medicine, Division of Infectious Diseases, Baltimore, Maryland, USA., Sauer L; Johns Hopkins University, School of Medicine, Department of Emergency Medicine, Baltimore, Maryland, USA., Cox AL; Johns Hopkins University, School of Medicine, Department of Medicine, Division of Infectious Diseases, Baltimore, Maryland, USA., Persaud D; Johns Hopkins University, School of Medicine, Department of Pediatrics, Division of Pediatric Infectious Diseases, Baltimore, Maryland, USA.; Johns Hopkins University, School of Medicine, Baltimore, Maryland, USA.; Johns Hopkins Bloomberg School of Public Health, Departments of Molecular Microbiology and Immunology, and International Health, Baltimore, Maryland, USA.
Jazyk:	angličtina
Zdroj:	The Journal of infectious diseases [J Infect Dis] 2021 Aug 16; Vol. 224 (4), pp. 606-615.
DOI:	10.1093/infdis/jiab285
Abstrakt:	Background: Multisystem inflammatory syndrome in children (MIS-C) is a severe clinical phenotype of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection that remains poorly understood. Methods: Hospitalized children <18 years of age with suspected coronavirus disease 2019 (COVID-19) (N = 53) were recruited into a prospective cohort study; 32 had confirmed COVID-19, with 16 meeting the US Centers for Disease Control criteria for MIS-C. Differences in nasopharyngeal viral ribonucleic acid (RNA) levels, SARS-CoV-2 seropositivity, and cytokine/chemokine profiles were examined, including after adjustments for age and sex. Results: The median ages for those with and without MIS-C were 8.7 years (interquartile range [IQR], 5.5-13.9) and 2.2 years (IQR, 1.1-10.5), respectively (P = .18), and nasopharyngeal levels of SARS-CoV-2 RNA did not differ significantly between the 2 groups (median 63 848.25 copies/mL versus 307.1 copies/mL, P = .66); 75% of those with MIS-C were antibody positive compared with 44% without (P = .026). Levels of 14 of 37 cytokines/chemokines (interleukin [IL]-1RA, IL-2RA, IL-6, IL-8, tumor necrosis factor-α, IL-10, IL-15, IL-18, monocyte chemoattractant protein [MCP]-1, IP-10, macrophage-inflammatory protein [MIP]-1α, MCP-2, MIP-1β, eotaxin) were significantly higher in children with MIS-C compared to those without, irrespective of age or sex (false discovery rate <0.05; P < .05). Conclusions: The distinct pattern of heightened cytokine/chemokine dysregulation observed with MIS-C, compared with acute COVID-19, occurs across the pediatric age spectrum and with similar levels of nasopharyngeal SARS-CoV-2 RNA. (© The Author(s) 2021. Published by Oxford University Press for the Infectious Diseases Society of America. All rights reserved. For permissions, e-mail: journals.permissions@oup.com.)
Databáze:	MEDLINE
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