The Dual Burden of HIV Infection and First-Episode Psychosis in Africa: A Systematic Review and Meta-Analysis.

Autor:	Chhagan U; Discipline of Psychiatry, College of Health Sciences, Nelson R Mandela School of Medicine., Ntlantsana V; Discipline of Psychiatry, College of Health Sciences, Nelson R Mandela School of Medicine., Tomita A, Chiliza B; Discipline of Psychiatry, College of Health Sciences, Nelson R Mandela School of Medicine., Paruk S; Discipline of Psychiatry, College of Health Sciences, Nelson R Mandela School of Medicine.
Jazyk:	angličtina
Zdroj:	The Journal of nervous and mental disease [J Nerv Ment Dis] 2021 Aug 01; Vol. 209 (8), pp. 600-608.
DOI:	10.1097/NMD.0000000000001366
Abstrakt:	Abstract: A systematic review and meta-analysis was conducted to synthesize data on HIV prevalence in individuals with first-episode psychosis (FEP) and to provide an overview of the association of HIV with clinical variables of FEP. Electronic databases were searched for quantitative studies published from January 1986 to November 2019. Meta-analyses were undertaken to calculate the pooled HIV/FEP proportion based on random effects modeling with inverse variance method. Seven HIV/FEP studies from sub-Sahara Africa (SSA) met inclusion criteria. The prevalence of HIV in FEP ranged from 24% to 40%, and FEP in people living with HIV (PLWHIV) ranged from 17% to 29%. The pooled proportion of HIV in FEP was 26% (95% confidence interval [CI], 10%-43%), with significant heterogeneity (n = 3, I2 = 89%, p < 0.01), and of FEP in PLWHIV was 23% (95% CI, 15%-32%), without significant heterogeneity (n = 3, I2 = 0%, p = 0.43). There are concerning levels of HIV and FEP comorbidity in SSA, necessitating an integrated health care service. (Copyright © 2021 Wolters Kluwer Health, Inc. All rights reserved.)
Databáze:	MEDLINE
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