Interim Results of the BYHEART Observational Study: Exogenous Phosphocreatine Effect on the Quality of life of Patients with Chronic Heart Failure.
| Autor: | Tereschenko SN; National Medical Research Center of Cardiology of the MoH of Russia, Moscow., Perepech NB; Federal State Budgetary Educational Institution of Higher Education St. Petersburg State University, St.-Petersburg., Cheremisina IA; Alfasigma Rus LLC, Moscow., Belov VN; Voronezh City Clinical Hospital №3, Voronezh., Vollis YA; Voronezh City Clinical Hospital №4, Voronezh., Ispiriyan AA; Voronezh City Clinical Hospital №3, Voronezh., Gridneva EA; Voronezh City Outpatient Hospital № 4, Voronezh., Ismailova AA; Republic of Dagestan Republican Clinical Hospital of Emergency Medical Care, Makhachkala., Maltseva MN; Clinical Health Resort named after M. Gorky, Voronezh., Melnikova EH; Central City Hospital, Azov., Moiseeva YN; City Clinical Hospital named after S.P. Botkin, Moscow., Petrenko MI; City Hospital of Emergency Medical Care named after V.I Lenin, Rostov region, Shakhty., Takhtamysheva MM; Medical Center 'Family', Rostov-on-Don., Titova TS; Belgorod Regional Clinical Hospital of St. Joasaph, Belgorod., Khaidarova FR; Clinical Hospital for War Veterans, Grozny., Savenkova AN; Voronezh City Clinical Hospital № 3, Voronezh. |
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| Jazyk: | Russian; English |
| Zdroj: | Kardiologiia [Kardiologiia] 2021 Jul 31; Vol. 61 (7), pp. 22-27. Date of Electronic Publication: 2021 Jul 31. |
| DOI: | 10.18087/cardio.2021.7.n1649 |
| Abstrakt: | Aim Improvement of quality of life is one of the most important goals for the treatment of patients with chronic heart failure (CHF). This study searched for ways to increase the efficiency of CHF treatment based on parameters of quality of life in CHF patients during and after the treatment with exogenous phosphocreatine (EP).Material and methods The effect of a single course of EP treatment on quality of life of patients with functional class (FC) II-IV CHF with reduced or mid-range left ventricular ejection fraction was studied as a part of the all-Russia prospective observational study BYHEART. The presence of FC II-IV CHF and a left ventricular ejection fraction <50 % were confirmed by results of 6-min walk test (6MWT) and findings of echocardiography after stabilization of the background therapy.Results An interim data analysis showed that the course of EP treatment was associated with a significant improvement of quality-of-life indexes as determined by the Minnesota Living with Heart Failure Questionnaire (LHFQ) total score. These indexes significantly increased and remained at a satisfactory level for 6 mos. following completion of the treatment course. Also, the treatment significantly beneficially influenced the clinical condition of patients (heart failure severity scale), results of 6MWT, and the increase in left ventricular ejection fraction.Conclusion The conclusions based on results of the interim analysis should be confirmed by results of the completed study. Complete results are planned to be published in 2022. |
| Databáze: | MEDLINE |
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