The role of pharmacies in haematopoietic stem cell transplantation process: A nationwide survey by Gruppo Italiano Trapianto di Midollo Osseo.

Autor: Faraci M; Hematopoietic stem Cell Transplantation Unit, Department of Hematology Oncology, Istituto G. Gaslini, Genova, Italy., Lorenzi I; Pharmacy Unit, Istituto G. Gaslini, Genova, Italy., Martino M; Stem Cell Transplant and Cellular Therapies Unit, Hemato-Oncology and Radiotherapy Department, 'Bianchi-Melacrino-Morelli' Hospital, Reggio Calabria, Italy., Mammoliti S; Trials Office GITMO, Gruppo Italiano per il Trapianto di Midollo Osseo, Cellule Staminali Emopoietiche e Terapia Cellulare, Genova, Italy., Iurilli V; Pharmacy Unit, Istituto G. Gaslini, Genova, Italy., Serra N; Department of Molecular Medicine and Medical Biotechnology, University Federico II of Naples, Naples, Italy., Giardino S; Hematopoietic stem Cell Transplantation Unit, Department of Hematology Oncology, Istituto G. Gaslini, Genova, Italy., Cannici C; Hematology Unit, AO SS Antonio e Biagio e Cesare Arrigo di Alessandria, Alessandria, Italy., Ciceri F; Hematology and Bone Marrow Transplantation Unit, IRCCS San Raffaele Scientific Institute, Milan, Italy.; San Raffaele Hospital, University Vita-Salute San Raffaele, Milan, Italy., Botti S; Hematology Unit, Azienda USL-IRCCS di Reggio Emilia, Reggio Emilia, Italy.
Jazyk: angličtina
Zdroj: Journal of clinical pharmacy and therapeutics [J Clin Pharm Ther] 2021 Dec; Vol. 46 (6), pp. 1665-1679. Date of Electronic Publication: 2021 Aug 16.
DOI: 10.1111/jcpt.13498
Abstrakt: What Is Known and Objective: The aim of this survey, conducted by the Gruppo Italiano per il Trapianto di Midollo Osseo (GITMO), was to evaluate the involvement of pharmacists in the haematopoietic stem cell transplant (HSCT) program in Italian adult and paediatric centres.
Methods: A 63-item online questionnaire was developed and sent to the Italian Transplant Programs on behalf of GITMO.
Results and Discussion: Overall, 54.7% of the Italian HSCT centres participated in the survey (88.5% adult, 7.7% paediatric, 3.8% mixed), of which 50% were in public hospitals and 50% affiliated with public universities. Just over 80% declared that a pharmacist is involved in the HSCT centre, and 86.5% reported the presence of a documentation system to signal of adverse events, accessible by physicians, nurses and pharmacists in 57.7%. Chemotherapy drugs were centralized in the pharmacy in 98.1% of HSCT centres, while parenteral nutrition was centralized in 55.8%. The use of off-label drugs was authorized by an internal committee and by the regional health authorities in 88.5% of the centres. On univariate analysis, few statistically significant differences were found on response frequencies between public hospitals and university centres or between HSCT centres performing only autologous stem cell transplantation versus other centres performing autologous and allogeneic stem cell transplantation.
What Is New and Conclusion: This survey suggests that there is good collaboration between pharmacists and physicians and nurses in Italian HSCT transplantation centres. The enhancement of pharmacists dedicated to HSCT programs could improve some problems, for example, the centralization of parenteral nutrition.
(© 2021 John Wiley & Sons Ltd.)
Databáze: MEDLINE
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