Lung Function and Symptoms in Post-COVID-19 Patients: A Single-Center Experience.

Autor:	Mumoli N; Department of Internal Medicine, ASST Ovest Milanese, Magenta (MI), Italy., Bonaventura A; Department of Internal Medicine, ASST Sette Laghi, Varese, Italy., Colombo A; Department of Internal Medicine, ASST Ovest Milanese, Magenta (MI), Italy., Vecchié A; Department of Internal Medicine, ASST Sette Laghi, Varese, Italy., Cei M; Department of Internal Medicine, Cecina Hospital, Cecina (Livorno), Italy., Vitale J; Department of Internal Medicine, ASST Ovest Milanese, Magenta (MI), Italy., Pavan L; Department of Internal Medicine, ASST Ovest Milanese, Magenta (MI), Italy., Mazzone A; Department of Internal Medicine, ASST Ovest Milanese, Magenta (MI), Italy., Dentali F; Department of Medicine and Surgery, Insubria University, Varese, Italy.
Jazyk:	angličtina
Zdroj:	Mayo Clinic proceedings. Innovations, quality & outcomes [Mayo Clin Proc Innov Qual Outcomes] 2021 Oct; Vol. 5 (5), pp. 907-915. Date of Electronic Publication: 2021 Aug 10.
DOI:	10.1016/j.mayocpiqo.2021.08.002
Abstrakt:	Objective: To address the lack of information about clinical sequelae of coronavirus disease 2019 (COVID-19). Patients and Methods: Previously hospitalized COVID-19 patients who were attending the outpatient clinic for post-COVID-19 patients (ASST Ovest Milanese, Magenta, Italy) were included in this retrospective study. They underwent blood draw for complete blood count, C-reactive protein, ferritin, D-dimer, and arterial blood gas analysis and chest high-resolution computed tomography (HRCT) scan. The primary endpoint was the assessment of blood gas exchanges after 3 months. Other endpoints included the assessment of symptoms and chest HRCT scan abnormalities and changes in inflammatory biomarkers after 3 months from hospital admission. Results: Eighty-eight patients (n = 65 men; 73.9%) were included. Admission arterial blood gas analysis showed hypoxia and hypocapnia and an arterial partial pressure of oxygen/fractional inspired oxygen ratio of 271.4 (interquartile range [IQR]: 238-304.7) mm Hg that greatly improved after 3 months (426.19 [IQR: 395.2-461.9] mm Hg, P <.001). Forty percent of patients were still hypocapnic after 3 months. Inflammatory biomarkers dramatically improved after 3 months from hospitalization. Fever, resting dyspnea, and cough were common at hospital admission and improved after 3 months, when dyspnea on exertion and arthralgias arose. On chest HRCT scan, more than half of individuals still presented with interstitial involvement after 3 months. Positive correlations between the interstitial pattern at 3 months and dyspnea on admission were found. C-reactive protein at admission was positively associated with the presence of interstitial involvement at follow-up. The persistence of cough was associated with presence of bronchiectasis and consolidation on follow-up chest HRCT scan. Conclusion: Whereas inflammatory biomarker levels normalized after 3 months, signs of lung damage persisted for a longer period. These findings support the need for implementing post-COVID-19 outpatient clinics to closely follow-up COVID-19 patients after hospitalization. (© 2021 THE AUTHORS.)
Databáze:	MEDLINE
Externí odkaz:	Zobrazit plný text záznamu