Iron deficiency anaemia in pregnancy: A contemporary review.
| Autor: | Benson CS; Department of Obstetrics, John Radcliffe Hospital, Oxford University Hospitals NHS Foundation Trust, Oxford, UK., Shah A; Department of Medicine, University of Oxford, Oxford, UK.; Nuffield Department of Anaesthesia, John Radcliffe Hospital, Oxford, UK., Frise MC; Department of Physiology, Anatomy and Genetics, University of Oxford, Oxford, UK.; Intensive Care Unit, Royal Berkshire Hospital, NHS Foundation Trust, Reading, UK., Frise CJ; Fetal Maternal Medicine Unit, John Radcliffe Hospital, Oxford University Hospitals NHS Foundation Trust, Oxford, UK.; Queen Charlotte's and Chelsea Hospital, Imperial College Healthcare NHS Trust, London, UK. |
|---|---|
| Jazyk: | angličtina |
| Zdroj: | Obstetric medicine [Obstet Med] 2021 Jun; Vol. 14 (2), pp. 67-76. Date of Electronic Publication: 2020 Jul 07. |
| DOI: | 10.1177/1753495X20932426 |
| Abstrakt: | Iron deficiency anaemia is a global health problem, which particularly affects pregnant women. Iron deficiency anaemia during pregnancy is associated with increased maternal and perinatal morbidity and mortality. Maternal iron deficiency may also be associated with neurocognitive deficits in infants. Iron requirements increase during pregnancy and are influenced by hepcidin, the master regulator of iron homeostasis. The enduring global burden of maternal anaemia suggests that currently employed iron supplementation strategies are suboptimal. Recent developments in our understanding of systemic and placental iron homeostasis may improve therapeutic effectiveness by altering the dose and frequency of oral iron. Intravenous iron appears to be a safe treatment to correct maternal anaemia rapidly but research on patient-centred outcomes and cost-effectiveness is needed. Future trials should be adequately powered to assess outcomes relevant to pregnant women. Competing Interests: Declaration of conflicting interests: The author(s) declared no potential conflicts of interest with respect to the research, authorship, and/or publication of this article. (© The Author(s) 2020.) |
| Databáze: | MEDLINE |
| Externí odkaz: |
|