BRAF V600E hot spot mutation in thyroid carcinomas: first Moroccan experience from a single-institution retrospective study.
| Autor: | Kaabouch M; Laboratory of Biology of Human Pathologies 'BioPatH', Center for Genomics of Human Pathologies 'GenoPatH'. Faculty of Science in Rabat. Mohammed V University in Rabat, Morocco.; Anatomic Pathology and Histology Service, Military Hospital Mohammed V of Rabat, Morocco. Equipe de Recherche en PathologieTumorale. Faculty of Medicine and Pharmacy of Rabat, University Mohammed V of Rabat.; Faculty of Sciences in Rabat. Centre National de l'Energie, des Sciences et Techniques Nucléaires, Rabat, Morocco., Chahdi H; Anatomic Pathology and Histology Service, Military Hospital Mohammed V of Rabat, Morocco. Equipe de Recherche en PathologieTumorale. Faculty of Medicine and Pharmacy of Rabat, University Mohammed V of Rabat., Azouzi N; UMR 8200 CNRS, Institut Gustave Roussy, Villejuif, France., Oukabli M; Anatomic Pathology and Histology Service, Military Hospital Mohammed V of Rabat, Morocco. Equipe de Recherche en PathologieTumorale. Faculty of Medicine and Pharmacy of Rabat, University Mohammed V of Rabat., Rharrassi I; Anatomic Pathology and Histology Service, Military Hospital Mohammed V of Rabat, Morocco. Equipe de Recherche en PathologieTumorale. Faculty of Medicine and Pharmacy of Rabat, University Mohammed V of Rabat., Boudhas A; Anatomic Pathology and Histology Service, Military Hospital Mohammed V of Rabat, Morocco. Equipe de Recherche en PathologieTumorale. Faculty of Medicine and Pharmacy of Rabat, University Mohammed V of Rabat., Jaddi H; Faculty of Sciences in Rabat. Centre National de l'Energie, des Sciences et Techniques Nucléaires, Rabat, Morocco., Ababou M; Laboratory of Biology of Human Pathologies 'BioPatH', Center for Genomics of Human Pathologies 'GenoPatH'. Faculty of Science in Rabat. Mohammed V University in Rabat, Morocco., Dakka N; Laboratory of Biology of Human Pathologies 'BioPatH', Center for Genomics of Human Pathologies 'GenoPatH'. Faculty of Science in Rabat. Mohammed V University in Rabat, Morocco., Boichard A; UMR 8200 CNRS, Institut Gustave Roussy, Villejuif, France.; Center for Personalized Cancer Therapy. UCSD Moores Cancer Center. 3855 Health Sciences Drive. La Jolla, CA 92093., Bakri Y; Laboratory of Biology of Human Pathologies 'BioPatH', Center for Genomics of Human Pathologies 'GenoPatH'. Faculty of Science in Rabat. Mohammed V University in Rabat, Morocco., Dupuy C; UMR 8200 CNRS, Institut Gustave Roussy, Villejuif, France., Al Bouzidi A; Anatomic Pathology and Histology Service, Military Hospital Mohammed V of Rabat, Morocco. Equipe de Recherche en PathologieTumorale. Faculty of Medicine and Pharmacy of Rabat, University Mohammed V of Rabat., El Hassani RA; Laboratory of Biology of Human Pathologies 'BioPatH', Center for Genomics of Human Pathologies 'GenoPatH'. Faculty of Science in Rabat. Mohammed V University in Rabat, Morocco. |
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| Jazyk: | angličtina |
| Zdroj: | African health sciences [Afr Health Sci] 2020 Dec; Vol. 20 (4), pp. 1849-1856. |
| DOI: | 10.4314/ahs.v20i4.40 |
| Abstrakt: | Background: The incidence of thyroid cancer is increasing worldwide at an alarming rate. BRAF V600E mutation is described to be associated with a worse prognostic of thyroid carcinomas, as well as extrathyroidal invasion and increased mortality. Objective: To our knowledge, there are no reported studies neither from Morocco nor from other Maghreb countries regarding the prevalence of BRAF V600E mutation in thyroid carcinomas. Here we aim to evaluate the frequency of BRAF V600E oncogene in Moroccan thyroid carcinomas. Methods: In this Single-Institution retrospective study realized in the Anatomic Pathology and Histology Service in the Military Hospital of Instruction Mohammed V 'HMIMV' in Rabat, we report, using direct genomic sequencing, the assessment of BRAF V600E in 37 thyroid tumors. Results: We detected BRAF V600E mutation exclusively in Papillary Thyroid Carcinomas 'PTC' with a prevalence of 28% (8 PTC out 29 PTC). Like international trends, Papillary Thyroid Carcinomas 'PTC' is more frequent than Follicular Thyroid Carcinomas 'FTC' and Anaplastic Thyroid Carcinomas 'ATC' (29 PTC, 7 FTC and 1 ATC). Conclusion: Our finding gives to the international community the first estimated incidence of this oncogene in Morocco showing that this prevalence falls within the range of international trends (30% to 90%) reported in distinct worldwide geographic regions. (© 2020 Kaabouch M et al.) |
| Databáze: | MEDLINE |
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