Biofluids profile of α-Klotho in patients with Parkinson's disease.

Autor: Sancesario GM; Biobank Unit, IRCCS Fondazione Santa Lucia, Rome, Italy., Di Lazzaro G; Department of Systems Medicine, University of Roma Tor Vergata, Rome, Italy; Neurology Unit, IRCCS Fondazione Policlinico Universitario A. Gemelli, Rome, Italy., Grillo P; Department of Systems Medicine, University of Roma Tor Vergata, Rome, Italy., Biticchi B; Biobank Unit, IRCCS Fondazione Santa Lucia, Rome, Italy., Giannella E; Biobank Unit, IRCCS Fondazione Santa Lucia, Rome, Italy., Alwardat M; Department of Systems Medicine, University of Roma Tor Vergata, Rome, Italy; Allied Medical Science Department, Division of Physical Therapy, Aqaba University of Technology, Aqaba, Jordan., Pieri M; Department of Experimental Medicine, University of Roma Tor Vergata, Rome, Italy., Bernardini S; Department of Experimental Medicine, University of Roma Tor Vergata, Rome, Italy., Mercuri NB; Department of Systems Medicine, University of Roma Tor Vergata, Rome, Italy; IRCCS Fondazione Santa Lucia, European Centre for Brain Research, Rome, Italy., Pisani A; Department of Brain and Behavioral Sciences, University of Pavia, Pavia, Italy; IRCCS Mondino Foundation, Pavia, Italy., Schirinzi T; Department of Systems Medicine, University of Roma Tor Vergata, Rome, Italy. Electronic address: t.schirinzi@yahoo.com.
Jazyk: angličtina
Zdroj: Parkinsonism & related disorders [Parkinsonism Relat Disord] 2021 Sep; Vol. 90, pp. 62-64. Date of Electronic Publication: 2021 Aug 10.
DOI: 10.1016/j.parkreldis.2021.08.004
Abstrakt: We measured α-Klotho in CSF and serum of PD patients at early stage of the disease, finding two distinct pools, the first increased, the second reduced. CSF α-Klotho was inversely associated with CSF α-synuclein levels. Our preliminary results suggest α-Klotho as potential biomarker or therapeutic target in PD.
(Copyright © 2021 Elsevier Ltd. All rights reserved.)
Databáze: MEDLINE
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